variants — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6797	Telaglenastat	CB 839,CB839,CB-839	transporter , Glutaminase , Autophagy
	Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.		transporter , Glutaminase , Autophagy
T22324	Ensartinib hydrochloride	Ensartinib dihydrochloride,X-396 dihydrochloride	Others , Trk receptor , c-Met/HGFR , ALK
	Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both...		Others , Trk receptor , c-Met/HGFR , ALK
T16813	RX-3117	fluorocyclopentenylcytosine,TV-1360	Nucleoside Antimetabolite/Analog
	RX-3117 (fluorocyclopentenylcytosine) is a novel a cytidine analog. RX-3117 displays anticancer activity in several cancer cell lines, including gemcitabine-resistant variants.		Nucleoside Antimetabolite/Analog
TQ0209	Ailanthone	Δ13-Dehydrochaparrinone	Androgen Receptor
	Ailanthone (Δ13-Dehydrochaparrinone) is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69 nM) and constitutively active truncated AR splice variants (IC50: 309 nM).		Androgen Receptor
T4618	BGG463	K 0859	Bcr-Abl , CDK
	BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.		Bcr-Abl , CDK
T15573	Inarigivir soproxil	SB9200	HCV Protease
	Inarigivir soproxil (SB9200) is an agonist of innate immunity. It also displays effective antiviral activity against resistant hepatitis C virus (HCV) variants (EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype ...		HCV Protease
TP1344	Luciferase		Others
	Luciferase is a flavin-dependent monooxygenase found in bioluminescent bacteria. Luciferase is an invaluable tool for identifying and characterizing functional variants, allowing investigations of gene expression, intrac...		Others
T4547	Grazoprevir	MK-5172	HCV Protease , SARS-CoV
	Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Ki of 0.01 nM (gt1a), 0.08 nM (gt2a), 0.90 nM (gt3a), 0.01 nM (gt1b), ...		HCV Protease , SARS-CoV
T7502	PF 05089771 tosylate		Sodium Channel
	PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8...		Sodium Channel
T81263	RMC-7977		Ras
	RMC-7977 is a reversible triple complex RAS inhibitor that exhibits broad-spectrum activity against mutant and wild-type (WT) variants of KRAS, NRAS, and HRAS. The compound is capable of triggering tumor regression and h...		Ras
T3550	X-376	Ensartinib,X-396	c-Met/HGFR , ALK
	X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inh...		c-Met/HGFR , ALK
T12065	Grazoprevir sodium salt	MK-5172 (sodium salt)	Others
	Grazoprevir sodium salt is a selective Hepatitis C virus NS3/4a protease inhibitor with broad activity across genotypes and resistant variants.		Others
T39650	Tadnersen	IONIS-C9Rx,BIIB078
	Tadnersen (BIIB078) is an antisense oligonucleotide (ASO) designed for the selective targeting of C9ORF72 transcript variants 1 and 3, specifically those carrying the expansion.
T27201	DPC-082	DPC 082
	DPC-082 is a reverse transcriptase inhibitor. DPC-082 exhibits low-nanomolar potency toward wild-type virus, L100I and K103N single-mutation variants, and multiplies amino acid-substituted HIV type 1 mutants.
T10141	4'-Ethynyl-2'-deoxyadenosine		Others
	4'-Ethynyl-2'-deoxyadenosine (4'-E-dA) is a nucleoside reverse transcriptase (RT) inhibitor. It is potent against drug-resistant HIV variants (EC50: 98 nM in MT-4 cells for anti-HIV-1 activity).		Others
TN3809	Dehydrojuncusol		HCV Protease
	Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is active against resistant HCV variants frequently found in patie...		HCV Protease
T21456	Grazoprevir hydrate	Grazoprevir,MK5172,MK 5172,MK-5172
	Grazoprevir, a second generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets, has good activity against a range of hepatitis C virus genotype variants, including some that are resistant to ...
T79612	Tyrosine kinase-IN-6		c-Met/HGFR
	Tyrosine kinase-IN-6 is a potent inhibitor of RON splice variants, demonstrating significant anticancer and antineoplastic effects [1].		c-Met/HGFR
T62068	Chitin synthase inhibitor 1
	Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor with IC50 of 0.12 mM. Chitin synthase inhibitor 1 potently inhibits drug-resistant fungi variants.
T26574	AG-7404	AG 7404
	AG-7404 is a potent protease inhibitor with anti-poliovirus activity. AG-7404 was active against all virus with EC50 values ranging from 0.080 to 0.674 μM. AG-7404 was fully active against V-073-resistant variants with E...