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Grazoprevir hydrate

Catalog No. T21456 CAS 1350462-55-3

Synonyms: Grazoprevir, MK5172, MK 5172, MK-5172

Grazoprevir, a second generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets, has good activity against a range of hepatitis C virus genotype variants, including some that are resistant to most currently used antiviral medications.

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Grazoprevir hydrate, CAS 1350462-55-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	Inquiry
50 mg	6-8 weeks	Inquiry
100 mg	6-8 weeks	Inquiry

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Grazoprevir, a second generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets, has good activity against a range of hepatitis C virus genotype variants, including some that are resistant to most currently used antiviral medications.
Targets&IC50	GT1a:0.01±0.01 nM (Ki), GT1b:0.01±<0.01 nM (Ki), GT2a:0.08±0.02 nM (Ki), GT2b:0.15±0.06 nM (Ki), GT3a:0.90±0.2 nM (Ki)

Synonyms	Grazoprevir, MK5172, MK 5172, MK-5172
Molecular Weight	784.92
Formula	C38H52N6O10S
CAS No.	1350462-55-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

H2O: Insoluble

References and Literature

1. Yeh WW, Fraser IP, Jumes P, Petry A, Lepeleire I, Robberechts M, Reitmann C, Van Dyck K, Huang X, Guo Z, Panebianco D, Nachbar RB, O'Mara E, Wagner JA, Butterton JR, Dutko FJ, Moiseev V, Kobalava Z, Hüser A, Visan S, Schwabe C, Gane E, Popa S, Ghicavii N, Uhle M, Wagner F. Antiviral Activity, Safety, and Tolerability of Multiple Ascending Doses of Elbasvir or Grazoprevir in Participants Infected With Hepatitis C Virus Genotype-1 or -3. Clin Ther. 2018 Apr 24. pii: S0149-2918(18)30094-8. doi: 10.1016/j.clinthera.2018.03.002. [Epub ahead of print] PubMed PMID: 29703432. 2. Zamor PJ, Vierling J, Ghalib R, Luketic V, Ravendhran N, Balart L, Robertson M, Hwang P, Hanna GJ, Nguyen BY, Barr E, Talwani R, Pearlman B. Elbasvir/grazoprevir in black adults with hepatitis C virus infection: a pooled analysis of phase 2/3 clinical trials. Am J Gastroenterol. 2018 Apr 26. doi: 10.1038/s41395-018-0053-4. [Epub ahead of print] PubMed PMID: 29695828. 3. Flamm SL, Bacon B, Curry MP, Milligan S, Nwankwo CU, Tsai N, Younossi Z, Afdhal N. Real-world use of elbasvir-grazoprevir in patients with chronic hepatitis C: retrospective analyses from the TRIO network. Aliment Pharmacol Ther. 2018 Apr 17. doi: 10.1111/apt.14635. [Epub ahead of print] PubMed PMID: 29665097. 4. Kanda T, Yasui S, Nakamura M, Nakamoto S, Takahashi K, Wu S, Sasaki R, Haga Y, Ogasawara S, Saito T, Kobayashi K, Kiyono S, Ooka Y, Suzuki E, Chiba T, Maruyama H, Moriyama M, Kato N. Successful retreatment with grazoprevir and elbasvir for patients infected with hepatitis C virus genotype 1b, who discontinued prior treatment with NS5A inhibitor-including regimens due to adverse events. Oncotarget. 2018 Mar 23;9(22):16263-16270. doi: 10.18632/oncotarget.24620. eCollection 2018 Mar 23. PubMed PMID: 29662642; PubMed Central PMCID: PMC5882333.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Grazoprevir hydrate 1350462-55-3 Grazoprevir Hydrate Grazoprevir MK5172 MK 5172 MK-5172 inhibitor inhibit

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