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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12351 | P53 and MDM2 proteins-interaction-inhibitor (racemic) | p53-and-mdm2-proteins-interaction-inhibitor-racemic | Others |
p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins. | |||
T12350 | P53 and MDM2 proteins-interaction-inhibitor dihydrochloride | Others | |
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins. | |||
TQ0280 | Feretoside | HSP | |
Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1). | |||
T4125 | HSF1A | HSP | |
HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis. | |||
T8189 | Dihydroberberine | Potassium Channel , HSP , HER | |
Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces Hsp90 expression and its interacti... | |||
T6248 | XL888 | HSP | |
XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis.... | |||
T21883 | Gedunin | HSP | |
Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation. | |||
T3487 | HSP70-IN-1 | Others , HSP | |
HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM). | |||
T3652 | KRIBB11 | Apoptosis , HSP | |
KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor. | |||
T6558 | KW-2478 | KW2478 | HSP |
KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM. | |||
T5008 | Teprenone | Tetraprenylacetone,Geranylgeranylacetone | HSP |
Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs). | |||
T6855 | HA15 | Apoptosis , GPR , Others , HSP , Autophagy | |
HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. | |||
T3527 | TRC051384 | TRC 051384 | HSP |
TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated ... | |||
T8858 | DTHIB | HSP | |
DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation. | |||
T11234 | ESI-08 | cAMP | |
ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation. | |||
T7010 | VER-155008 | VER155008 | GPR , HSP , Autophagy |
VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90. | |||
T14049 | 5-FAM SE | Others | |
5-FAM SE is a single isomer,it has been used to prepare various small fluorescent molecules. It is one of the most popular green fluorescent reagents used for labeling peptides, proteins and nucleotides. | |||
TN6729 | Azadiradione | AZD | Others |
Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica | |||
T2309 | Ganetespib | STA-9090 | Apoptosis , HSP , HIF |
Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. | |||
T16994 | Pimitespib | TAS-116 | HSP |
Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively). |