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Teprenone

Name: Teprenone
Brand: TargetMol
SKU: T5008
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5008Cas No. 6809-52-5

Alias Tetraprenylacetone, Geranylgeranylacetone

Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).

Teprenone

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Purity: 99.96%

Catalog No. T5008Alias Tetraprenylacetone, GeranylgeranylacetoneCas No. 6809-52-5

Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$35	In Stock	In Stock
100 mg	$50	In Stock	In Stock
500 mg	$98	In Stock	In Stock
1 g	$148	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.96%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).
In vitro	Teprenone, known as Geranylgeranylacetone, is an inducer of Heat Shock Proteins (HSPs) and, at a concentration of 1 μM, notably mitigates ethanol-induced exfoliation and lowers lactate dehydrogenase (LDH) release in gastric mucosal cells. This compound elevates the HSC70 level over time and rapidly boosts stress-inducible HSP90, HSP70, and HSP60 concentrations within 30-60 minutes, also activating heat shock factor 1. At dosages ranging from 0 to 20 µM, Teprenone marginally increases the viability of human umbilical vein endothelial cells (HUVEC) post-irradiation (IR), and while 10 µM of Teprenone does not affect HUVEC migration and invasion, it notably promotes HUVEC tube formation and wound healing, with or without IR exposure. Furthermore, at this concentration, Teprenone fosters angiogenesis by inducing VEGF and eNOS expression in HUVECs.
In vivo	Teprenone (200 mg/kg, p.o.) upregulates HSP70 mRNA in rats, a process amplified by mucosal stress in Teprenone-pretreated versus vehicle-pretreated rats. It significantly reduces stress-induced ulcer formation after 2 and 4 hours in rats[1]. Teprenone also enhances HSP72 expression, mitigates RGC loss, optic nerve damage, and apoptosis, and boosts HSP72 levels in a rat glaucoma model[2]. Additionally, Teprenone protects against radiation-induced intestinal injury in mice.
Synonyms	Tetraprenylacetone, Geranylgeranylacetone

Chemical Properties

Molecular Weight	330.55
Formula	C₂₃H₃₈O
Cas No.	6809-52-5
Smiles	C(CCC=C(CCC=C(C)C)C)(=CCCC(=CCCC(C)=O)C)C
Relative Density.	0.872g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (75.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (6.05 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0253 mL	15.1263 mL	30.2526 mL	151.2630 mL
5 mM	0.6051 mL	3.0253 mL	6.0505 mL	30.2526 mL
10 mM	0.3025 mL	1.5126 mL	3.0253 mL	15.1263 mL
20 mM	0.1513 mL	0.7563 mL	1.5126 mL	7.5632 mL
50 mM	0.0605 mL	0.3025 mL	0.6051 mL	3.0253 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc