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Azadiradione

Catalog No. TN6729 CAS 26241-51-0

Synonyms: AZD

Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica

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Azadiradione, CAS 26241-51-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 133.00
5 mg	In stock	$ 302.00
10 mg	In stock	$ 543.00
25 mg	In stock	$ 817.00
50 mg	In stock	$ 1,130.00
100 mg	In stock	$ 1,530.00
1 mL * 10 mM (in DMSO)	In stock	$ 372.00

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Purity: 99.91%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica

In vitro

Azadiradione (AZD)?ameliorates toxicity due to protein aggregation in cell and fly models of polyglutamine expansion diseases to a great extent.?All these effects are correlated with activation of HSF1 function and expression of its target protein chaperone genes.?Notably, HSF1 activation by AZD is independent of cellular HSP90 or proteasome function.?Furthermore, we show that AZD directly interacts with purified human HSF1 with high specificity, and facilitates binding of HSF1 to its recognition sequence with higher affinity.?These unique findings qualify AZD as an ideal lead molecule for consideration for drug development against NDs that affect millions worldwide[1].

Synonyms	AZD
Molecular Weight	450.57
Formula	C28H34O5
CAS No.	26241-51-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (122.07 mM)

References and Literature

1. Nelson V K , Ali A , Dutta N , et al. Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1[J]. Oncotarget, 2016, 7(48):78281-78296. 2. Singh, Kumar B , Vatsa, et al. Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington's Disease[J]. Molecular Neurobiology, 2018.

Related compound libraries

This product is contained In the following compound libraries：

RO5 Drug-like Natural Product Library Bioactive Compound Library Natural Product Library for HTS Natural Product Library Selected Plant-Sourced Compound Library NO PAINS Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Azadiradione 26241-51-0 Others anti-nociceptive antimycobacterial Inhibitor Heat shock proteins inhibit HSF1 Activator HSP AZD anti-inflammatory activities bioactive limonoid inhibitor

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