Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 455.00 | |
50 mg | In stock | $ 672.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 168.00 |
Description | ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation. |
Targets&IC50 | EPAC2:8.4 μM |
In vitro | ESI-08 (25 μM) does not alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1]. |
Molecular Weight | 353.48 |
Formula | C20H23N3OS |
CAS No. | 301177-43-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (141.45 mM)
You can also refer to dose conversion for different animals. More
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ESI-08 301177-43-5 GPCR/G Protein cAMP EPAC2 exchange proteins ESI08 EPAC Ras inhibit EPAC1 ESI 08 Inhibitor inhibitor