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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T64096 | Integrase-LEDGF/p75 allosteric inhibitor 1 | ||
Integrase-LEDGF/p75 allosteric inhibitor 1 is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. It inhibits HIV-1 DNA integration and exhibits antiviral effects, acting on the HIV-1 recombinant mo... | |||
T4182 | Lavendustin B | Tyrosinase , transporter , HIV Protease | |
Lavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75). | |||
T11861 | LM11A-31 dihydrochloride | Others | |
LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagoni... | |||
T6712 | Tyrphostin AG 879 | AG 879 | Apoptosis , EGFR , Trk receptor , HER , PDGFR |
Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR. | |||
T9292 | ALE-0540 | ALE0540 | Others , Trk receptor |
ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors. | |||
T39755 | Pirmitegravir | STP0404 | HIV Protease |
Pirmitegravir (STP0404) is a potent and selective inhibitor of allosteric integrase (ALLINI) targeting the LEDGF/p75 binding site. Pirmitegravir inhibits PBMC. Pirmitegravir inhibits PBMC.Pirmitegravir has significant an... | |||
T74097 | THX-B | ||
THX-B, a potent non-peptidic antagonist of the neurotrophin receptor p75 (p75 NTR), is utilized in the study of diabetic kidney disease, neurodegenerative, and inflammatory disorders [1] [2] [3]. | |||
T17314 | (±)-BI-D | Others | |
(±)-BI-D is an effective ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site (IC50: 2.4–2.9 μM). | |||
TP2069 | BDNF (human) | ||
Member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. Enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative ... | |||
T69782 | GS-9822 | ||
GS-9822 is a novel LEDGIN, an inhibitor that targets the binding pocket of LEDGF/p75 which is a cellular cofactor that substantially contributes to HIV integration site selection, displaying a block-and-lock phenotype in... | |||
T75831 | NTR 368 TFA | ||
NTR 368 TFA, a peptide derived from the p75 neurotrophin receptor (p75NTR) and corresponding to residues 368-381 of the human receptor, exhibits a helix-forming propensity in the presence of micellar lipid. It is a poten... | |||
T76813 | Bedinvetmab | ||
Bedinvetmab (ZTS-00508841), a canine monoclonal antibody (mAb) designed to target nerve growth factor (NGF), prevents NGF from interacting with its receptors, tropomyosin receptor kinase A (trkA) and p75 neurotrophin rec... | |||
T78282 | Tanezumab | RN-624,PF 4383119 | |
Tanezumab (RN-624) is a high-affinity, specific humanized anti-NGF monoclonal antibody (mAb) that inhibits nerve growth factor (NGF) from binding to its p75 and TrkA receptors in the peripheral nervous system. It is util... |