p75 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T64096	Integrase-LEDGF/p75 allosteric inhibitor 1
	Integrase-LEDGF/p75 allosteric inhibitor 1 is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. It inhibits HIV-1 DNA integration and exhibits antiviral effects, acting on the HIV-1 recombinant mo...
T4182	Lavendustin B		Tyrosinase , transporter , HIV Protease
	Lavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75).		Tyrosinase , transporter , HIV Protease
T11861	LM11A-31 dihydrochloride		Others
	LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagoni...		Others
T6712	Tyrphostin AG 879	AG 879	Apoptosis , EGFR , Trk receptor , HER , PDGFR
	Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.		Apoptosis , EGFR , Trk receptor , HER , PDGFR
T9292	ALE-0540	ALE0540	Others , Trk receptor
	ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors.		Others , Trk receptor
T39755	Pirmitegravir	STP0404	HIV Protease
	Pirmitegravir (STP0404) is a potent and selective inhibitor of allosteric integrase (ALLINI) targeting the LEDGF/p75 binding site. Pirmitegravir inhibits PBMC. Pirmitegravir inhibits PBMC.Pirmitegravir has significant an...		HIV Protease
T74097	THX-B
	THX-B, a potent non-peptidic antagonist of the neurotrophin receptor p75 (p75 NTR), is utilized in the study of diabetic kidney disease, neurodegenerative, and inflammatory disorders [1] [2] [3].
T17314	(±)-BI-D		Others
	(±)-BI-D is an effective ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site (IC50: 2.4–2.9 μM).		Others
TP2069	BDNF (human)
	Member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. Enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative ...
T69782	GS-9822
	GS-9822 is a novel LEDGIN, an inhibitor that targets the binding pocket of LEDGF/p75 which is a cellular cofactor that substantially contributes to HIV integration site selection, displaying a block-and-lock phenotype in...
T75831	NTR 368 TFA
	NTR 368 TFA, a peptide derived from the p75 neurotrophin receptor (p75NTR) and corresponding to residues 368-381 of the human receptor, exhibits a helix-forming propensity in the presence of micellar lipid. It is a poten...
T76813	Bedinvetmab
	Bedinvetmab (ZTS-00508841), a canine monoclonal antibody (mAb) designed to target nerve growth factor (NGF), prevents NGF from interacting with its receptors, tropomyosin receptor kinase A (trkA) and p75 neurotrophin rec...
T78282	Tanezumab	RN-624,PF 4383119
	Tanezumab (RN-624) is a high-affinity, specific humanized anti-NGF monoclonal antibody (mAb) that inhibits nerve growth factor (NGF) from binding to its p75 and TrkA receptors in the peripheral nervous system. It is util...