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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12421 | PF-04885614 | Sodium Channel | |
PF-04885614 is a potent inhibitor of NaV1.8, has potential for neurological and neurodevelopmental diseases treatment. | |||
T39252 | TAK-418 | Histone Demethylase | |
TAK-418 is a selective and orally active inhibitor of LSD1/KDM1A enzyme with an IC50 of 2.9 nM. TAK-418 unlocks abnormal epigenetic mechanisms and improves autism symptoms in models of neurodevelopmental disorders. | |||
T77566 | (3aR,9aR)-Fluparoxan | Adrenergic Receptor | |
(3aR,9aR)-Fluparoxan is a highly selective and potent adrenergic receptor α2B antagonist for the prevention, amelioration or treatment of neurodevelopmental disorders and neurodegenerative diseases. | |||
T77565 | Fluparoxan hydrochloride | Adrenergic Receptor | |
Fluparoxan hydrochloride is a highly selective and potent α2-adrenoceptor antagonist for the prevention, amelioration or treatment of neurodevelopmental disorders and neurodegenerative diseases. | |||
T39940 | Plazinemdor | ||
Plazinemdor is an NMDA receptor positive allosteric modulator with potential applications in psychiatric, neurological, neurodevelopmental disorders, and diseases of the nervous system. | |||
T74649 | Rugonersen | ||
Rugonersen (RG6091; RO7248824), a locked-nucleic acid (LNA)-modified antisense oligonucleotide (ASO), reduces the silencing of ubiquitin-protein ligase E3A (UBE3A). This compound is significant in the research of Angelma... | |||
TN2775 | 2-Methoxystypandrone | MMP , BCL , IκB/IKK , GSK-3 , TNF , NOS , NF-κB , Wnt/beta-catenin , COX , JAK , STAT | |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrit... |