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Search Results for " lyase "

20

Compounds

Cat No. Product Name Synonyms Targets
T64354 Cystathionine-γ-lyase-IN-1 SHIP-2a Others
Cystathionine-γ-lyase-IN-1 (SHIP-2a) is a selective inhibitor of cystathionine γ-lyase (CSE) enzyme (IC50= 6.3 μM).
T79929 L-Methionine γ-lyase Methionine lyase
L-Methionine γ-lyase (Methionine lyase), a multifaceted enzyme in the γ-family of pyridoxal-5’-phosphate (PLP)-dependent enzymes, catalyzes the α, γ-elimination of L-methionine and homocysteine. This enzyme exhibits anti...
T79927 Pectate Lyase
Pectate Lyase, an enzyme secreted by plant pathogens, is essential for pectin degradation and plays a vital role in fungal virulence. Additionally, it triggers plant immune responses, further contributing to its virulenc...
T78355 Cystathionine β-lyase
Cystathionine β-lyase, an enzyme crucial for bacterial virulence [1], catalyzes the conversion of cystathionine into homocysteine, representing the penultimate step in the biosynthesis of methionine.
T76165 N-Acetylneuraminate lyase (CgNal)
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)), a class I aldolase frequently utilized in biochemical research, catalyzes the reversible condensation of pyruvate and N-acetyl-d-mannosamine (ManNAc), pro...
T83910 S1PL-IN-31 Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31
S1PL-IN-31 is a dual-function chemical compound acting as an inhibitor of sphingosine-1-phosphate (S1P) lyase with an IC50 value of 210 nM and as an antagonist of the Smoothened (Smo) receptor with an IC50 of 440 nM. Dem...
T11590 (-)-Hydroxycitric acid Garcinia acid ATP Citrate Lyase
(-)-Hydroxycitric acid (Garcinia acid) (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. It is a potent and competitive inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses fatty aci...
T2337 BMS-303141 BMS 303141 ATP Citrate Lyase
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
T7424 NDI-091143 ATP Citrate Lyase
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate binding via an unexpected mechanism of inhibition.
T16861 SB 204990 ATP Citrate Lyase
SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
T22967 MEDICA16 MEDICA 16 GPR , Others , ATP Citrate Lyase
MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle with an increase in insu...
T8336 OGG1-IN-08 OGG1-IN-O8 Others
OGG1-IN-08 (OGG1-IN-O8) is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1;IC50 : 0.35 μM)
T12045 (-)-Hydroxycitric acid lactone Garcinia lactone ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, which catalyzes the extramitochondrial cleavage of citrate to oxaloac...
T5544 2-Furoic acid Furan-2-carboxylic acid Anti-infection , ATP Citrate Lyase , Endogenous Metabolite , Acyltransferase
2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid can reduce serum cholesterol and triglyceride levels and has anti-lipidemic effects.
T3625 Bempedoic acid ETC1002,ESP-55016,ETC 1002,ETC-1002 ATP Citrate Lyase , AMPK
Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic ...
T11589 Hydroxycitric acid tripotassium hydrate Potassium citrate monohydrate ATP Citrate Lyase , HIF/HIF Prolyl-Hydroxylase , HIF
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tr...
T0256 Citric acid trilithium salt tetrahydrate Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate Dehydrogenase , GSK-3 , HIF/HIF Prolyl-Hydroxylase , Antibacterial , GluR
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways...
T13312L Seviteronel VT-464 Others
Seviteronel is an effective CYP17 lyase inhibitor (h-Lyase IC50=69 nM). In a hamster model of androgen biosynthesis inhibition, it demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral...
T6050 TAK-700 (S/R)-Orteronel,Orteronel P450
TAK-700 (Orteronel) (Orteronel) is a potent and highly selective human 17, 20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). Phase 3.
T77627 Opevesostat ODM208,ODM-208 P450
Opevesostat (ODM-208) is an inhibitor of lyase (CYP11A1) (the enzyme cleavage cholesterol side chain).

Compounds

Cystathionine-γ-lyase-IN-1
T64354
Synonym: SHIP-2a
Target: Others
L-Methionine γ-lyase
T79929
Synonym: Methionine lyase
Target:
Pectate Lyase
T79927
Synonym:
Target:
Cystathionine β-lyase
T78355
Synonym:
Target:
N-Acetylneuraminate lyase (CgNal)
T76165
Synonym:
Target:
S1PL-IN-31
T83910
Synonym: Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31
Target:
(-)-Hydroxycitric acid
T11590
Synonym: Garcinia acid
Target: ATP Citrate Lyase
BMS-303141
T2337
Synonym: BMS 303141
Target: ATP Citrate Lyase
NDI-091143
T7424
Synonym:
Target: ATP Citrate Lyase
SB 204990
T16861
Synonym:
Target: ATP Citrate Lyase
MEDICA16
T22967
Synonym: MEDICA 16
Target: GPR, Others, ATP Citrate Lyase
OGG1-IN-08
T8336
Synonym: OGG1-IN-O8
Target: Others
(-)-Hydroxycitric acid lactone
T12045
Synonym: Garcinia lactone
Target: ATP Citrate Lyase
2-Furoic acid
T5544
Synonym: Furan-2-carboxylic acid
Target: Anti-infection, ATP Citrate Lyase, Endogenous Metabolite, Acyltransferase
Bempedoic acid
T3625
Synonym: ETC1002,ESP-55016,ETC 1002,ETC-1002
Target: ATP Citrate Lyase, AMPK
Hydroxycitric acid tripotassium hydrate
T11589
Synonym: Potassium citrate monohydrate
Target: ATP Citrate Lyase, HIF/HIF Prolyl-Hydroxylase, HIF
Citric acid trilithium salt tetrahydrate
T0256
Synonym: Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate
Target: Dehydrogenase, GSK-3, HIF/HIF Prolyl-Hydroxylase, Antibacterial, GluR
Seviteronel
T13312L
Synonym: VT-464
Target: Others
TAK-700
T6050
Synonym: (S/R)-Orteronel,Orteronel
Target: P450
Opevesostat
T77627
Synonym: ODM208,ODM-208
Target: P450
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TargetMol