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BMS-303141

Name: BMS-303141
Brand: TargetMol
SKU: T2337
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2337Cas No. 943962-47-8

Alias BMS 303141

BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).

BMS-303141

🥰Excellent

Purity: 99.47%

Catalog No. T2337Alias BMS 303141Cas No. 943962-47-8

BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).

Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$61	In Stock
10 mg	$79	In Stock
25 mg	$143	In Stock
50 mg	$282	In Stock
100 mg	$443	In Stock
500 mg	$992	In Stock
1 mL x 10 mM (in DMSO)	$63	In Stock

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Batch Information

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Purity:99.47%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
Targets&IC50	ACL:0.13 μM
In vitro	BMS-303141 shows inhibition of total lipid syntheses with an IC50 of 8 μM in HepG2 cells. BMS-303141 shows no cytotoxicity up to 50 lM under a cell-based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity[1].
In vivo	Chronic oral administration of BMS-303141 to mice on a high-fat diet reduces plasma cholesterol and triglycerides by approximately 20-30% and fasting plasma glucose by 30-50%. Continued treatment with BMS-303141 gradually inhibits weight gain and decreases adiposity without affecting food consumption. BMS-303141 displays an oral bioavailability of 55% and a relatively brief half-life of 2.1 hours[1].
Synonyms	BMS 303141

Chemical Properties

Molecular Weight	424.3
Formula	C₁₉H₁₅Cl₂NO₄S
Cas No.	943962-47-8
Smiles	COc1ccc(cc1NS(=O)(=O)c1cc(Cl)cc(Cl)c1O)-c1ccccc1
Relative Density.	1.462 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (129.63 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3568 mL	11.7841 mL	23.5682 mL	117.8412 mL
5 mM	0.4714 mL	2.3568 mL	4.7136 mL	23.5682 mL
10 mM	0.2357 mL	1.1784 mL	2.3568 mL	11.7841 mL
20 mM	0.1178 mL	0.5892 mL	1.1784 mL	5.8921 mL
50 mM	0.0471 mL	0.2357 mL	0.4714 mL	2.3568 mL
100 mM	0.0236 mL	0.1178 mL	0.2357 mL	1.1784 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc