lifespan — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4S1820	Parishin	Parishin A	Others
	Parishin (Parishin A) A is isolated from the rhizomes of Gastrodia elata. It has good neuroprotective effects against brain disorders.		Others
T62461	Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine		Others
	Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine can be used to alter eukaryotic lifespan.		Others
T3333	Cyclogalegenin	Cyclogalegigenin,Cyclogalagenin,Astramembrangenin,Cycloastragenol	Telomerase
	Cyclogalegenin (Astramembrangenin) is able to elongate telomeres, resulting in increased lifespan of the animals.		Telomerase
T77612	WAY-620472		PPAR
	WAY-620472 is a PPAR regulator that can be used to alter the lifespan of eukaryotes.		PPAR
T67945	WAY-620473		PARP
	WAY-620473 is a potent PARP-1 inhibitor with antitumor activity and alters eukaryotic lifespan.		PARP
TN2309	Withanolide A		EGFR , TNF , NF-κB
	Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.		EGFR , TNF , NF-κB
T77604	WAY-326766		CFTR
	WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).		CFTR
T38376	2-O-(α-D-Glucopyranosyl)glycerol	2-alphaGG	Others
	2-O-(α-D-Glucopyranosyl)glycerol (2-alphaGG) is found in a few bacteria and plants growing in harsh environments, and may extend the lifespan of budding yeast and erythrosporidium by increasing osmotic response.		Others
T15646	KBU2046		Others
	KBU2046 is an orally administered compound that inhibits cell motility and invasion, effectively suppressing cancer metastasis and extending lifespan. This compound uniquely targets and binds to chaperone heterocomplexes...		Others
T60001	Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)	3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide	Sirtuin
	Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) is a sirtuin modulator and useful for increasing the lifespan of a cell, and treating and/or pre...		Sirtuin
TMS1461	Qingyangshengenin B	Otophylloside B	Beta Amyloid
	Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mR...		Beta Amyloid
T82638	Cyclohexyl [3,5-bis(methylthio)-4-isothiazolyl]carbamate
	Cyclohexyl [3,5-bis(methylthio)-4-isothiazolyl]carbamate is a chemical agent capable of modulating the lifespan of eukaryotic organisms [1].
T21921	Valeroyl Salicylate	2-Valeryloxybenzoic acid	Others
	Valeroyl Salicylate (2-Valeryloxybenzoic acid) has anti-inflammatory properties that extend lifespan, delay the age-related decline in spontaneous activity, and improve stress tolerance.		Others
T38515	Ascr#7
	Ascr#7, an ascaroside-based hormonal compound, plays a significant role in nematode physiology. It is specifically expressed throughout the various stages of nematode development. Notably, ascarosides exhibit the capabil...
T35670	Miro1 Reducer
	Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochon...
T62002	Topoisomerase I inhibitor 7
	Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lympho...
T72483	Sirtuin modulator 4
	Sirtuin Modulator 4, a sirtuin modulator, exhibits an inhibitory effect on SIRT1, presenting an EC 50 value ranging from 51-100 μM. It is potentially useful in research aimed at prolonging cell lifespan and preventing a ...
T74743	M47
	M47, a small molecule, selectively targets and destabilizes Cryptochrome 1 (CRY1), promoting its degradation within the nucleus. This compound not only initiates apoptosis in Ras-transformed P53-deficient mouse skin fibr...
T83861	Bactobolamine
	Bactobolamine, an immunosuppressant, suppresses IL-2 production in CTLL cells at a concentration of 200 µg/ml and extends heart allograft survival in both MHC-compatible and MHC-incompatible rat pairings at a dosage of 2...
T69600	Spermidine-d6
	Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µ...