Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 152.00 | |
5 mg | In stock | $ 372.00 | |
10 mg | In stock | $ 556.00 | |
25 mg | In stock | $ 896.00 | |
50 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 392.00 |
Description | Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. |
In vitro | A quantitative structure activity relationship (QSAR) model was developed by a forward stepwise multiple linear regression method to predict the activity of Withanolide Analogs against human breast cancer. The most effective QSAR model for anticancer activity against the SK-Br-3 cell showed the best correlation with activity (r2=0.93 and rCV2 =0.90). Similarly, cross-validation regression coefficient (rCV2=0.85) of the best QSAR model against the MCF7/BUS cells showed a high correlation (r2=0.91). In particular, compounds CID 73621, CID 435144, CID 301751 and CID 3372729 have a marked antiproliferative activity against the MCF7/BUS cells, while 2,3-dihydrowithaferin A-3-beta-O-sulfate, withanolide 5, Withanolide A, withaferin A, CID 10413139, CID 11294368, CID 53477765, CID 135887, CID 301751 and CID 3372729 have a high activity against the Sk-Br-3 cells compared to standard drugs 5-fluorouracil (5-FU) and camptothecin[1] |
Source |
Molecular Weight | 470.6 |
Formula | C28H38O6 |
CAS No. | 32911-62-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (116.87 mM)
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Withanolide A 32911-62-9 Angiogenesis Apoptosis JAK/STAT signaling NF-Κb Tyrosine Kinase/Adaptors NF-κB TNF EGFR inhibit Inhibitor inhibitor