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Withanolide A

Catalog No. TN2309   CAS 32911-62-9

Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.

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Withanolide A Chemical Structure
Withanolide A, CAS 32911-62-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 152.00
5 mg In stock $ 372.00
10 mg In stock $ 556.00
25 mg In stock $ 896.00
50 mg In stock $ 1,220.00
1 mL * 10 mM (in DMSO) In stock $ 392.00
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Purity: 98.49%
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Biological Description
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Storage & Solubility Information
Description Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
In vitro A quantitative structure activity relationship (QSAR) model was developed by a forward stepwise multiple linear regression method to predict the activity of Withanolide Analogs against human breast cancer. The most effective QSAR model for anticancer activity against the SK-Br-3 cell showed the best correlation with activity (r2=0.93 and rCV2 =0.90). Similarly, cross-validation regression coefficient (rCV2=0.85) of the best QSAR model against the MCF7/BUS cells showed a high correlation (r2=0.91). In particular, compounds CID 73621, CID 435144, CID 301751 and CID 3372729 have a marked antiproliferative activity against the MCF7/BUS cells, while 2,3-dihydrowithaferin A-3-beta-O-sulfate, withanolide 5, Withanolide A, withaferin A, CID 10413139, CID 11294368, CID 53477765, CID 135887, CID 301751 and CID 3372729 have a high activity against the Sk-Br-3 cells compared to standard drugs 5-fluorouracil (5-FU) and camptothecin[1]
Source
Molecular Weight 470.6
Formula C28H38O6
CAS No. 32911-62-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (116.87 mM)

TargetMolReferences and Literature

1. Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer.Drug Des Devel Ther. 2017 Jun 22;11:1859-1870.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Fibrosis Compound Library Transcription Factor-Targeted Compound Library Anti-Breast Cancer Compound Library Apoptosis Compound Library NO PAINS Compound Library Antioxidant Compound Library Pyroptosis Compound Library NF-κB Signaling Compound Library Human Endogenous Metabolite Compound Library Plus RO5 Drug-like Natural Product Library

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Keywords

Withanolide A 32911-62-9 Angiogenesis Apoptosis JAK/STAT signaling NF-Κb Tyrosine Kinase/Adaptors NF-κB TNF EGFR inhibit Inhibitor inhibitor

 

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