leukemias — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6311	Bafetinib	NS-187,INNO-406	Bcr-Abl , Src , Autophagy
	Bafetinib (INNO-406) (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and less effective to c-Kit and PDGFR.		Bcr-Abl , Src , Autophagy
T21503	(E/Z)-Zotiraciclib	(E/Z)-TG02,(E/Z)-SB1317	FLT , JAK , CDK
	(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.		FLT , JAK , CDK
T0707L	Cyclophosphamide		DNA Alkylator/Crosslinker , DNA , MRP
	Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.		DNA Alkylator/Crosslinker , DNA , MRP
T3099	Pinometostat	EPZ-5676	Histone Methyltransferase
	Pinometostat (EPZ-5676) has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute Lymphocytic Leukemia, among others.		Histone Methyltransferase
T3078	SGI-1776	SGI-1776 free base,Pim-Kinase Inhibitor IX	Apoptosis , FLT , Pim , Autophagy
	SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.		Apoptosis , FLT , Pim , Autophagy
T12943	SNDX-5613		Epigenetic Reader Domain , Histone Methyltransferase
	SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias.		Epigenetic Reader Domain , Histone Methyltransferase
T26754	BC-23	NSC 45382,BC 23,BC23,NSC-45382,NSC45382	Proteasome
	BC-23 (NSC 45382) is a potent proteasome inhibitor with antitumor and antimicrobial activity.BC-23 inhibits the CT-L activity of the proteasome and is used in the study of leukemias, lymphomas, gliomas, breast cancer, an...		Proteasome
T77339	BRD4-IN-4		Epigenetic Reader Domain
	BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line and arrests the cells in G1 phase.BRD4-IN-4 can be used to study MLL...		Epigenetic Reader Domain
T70563	KC-11404
	KC-11404 is an LTB4 inhibitor for the treatment of b-cell leukemias and lymphomas, potently inhibiting histamine, platelet activating factor and 5-lipoxygenase.
T74096	Prednimustine
	Prednimustine (Leo 1031;NSC 134087) is the ester formed from Prednisolone and Chlorambucil . Prednimustine can be used for leukemias and lymphomas research [1] .
T69130	Zorubicin	Rubidazon ; Rubidazone,Rubidazone,Rubidazon
	Zorubicin (Rubidazon), a Daunorubicin derivative, inhibits DNA polymerases and interacts with topoisomerase II. It is utilized in the research of acute leukemias and sarcomas [1] [2] [3] [4] [5].
T33737	NSC 109555	NSC-109555,DDUG dimethanesulfonate,NSC109555,DDUG diMS
	NSC 109555 is a selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM...
T68502	Dibrospidium Free Base
	Dibrospidium Free Base is a dispirotripiperazine derivative and alkylating agent with potential antineoplastic and anti-inflammatory activities. The duration of DNA synthesis inhibition in tumor cells was found to correl...