lethality — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN2252	Syrosingopine		Dopamine Receptor
	Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.		Dopamine Receptor
T9165	AZD5305		PARP
	AZD5305 is a potent, selective and oral active PARP inhibitor.		PARP
TMA2613	Cyclo(Pro-Leu)	Cyclo-L-leu-L-pro,Cyclo-L-prolyl-L-leucine,Cyclo(leucyloprolyl)	Others
	Cyclo(Pro-Leu) (Cyclo-L-prolyl-L-leucine) is a marine-derived natural product with brine shrimp lethality.		Others
T23636	Adenosine N1-oxide	ANO,1-Oxoadenosine,Adenosine N1 oxide,Adenosine, 1-oxide	Immunology/Inflammation related
	Adenosine N1-oxide (1-Oxoadenosine), which is found in royal jelly, inhibited the secretion of inflammatory mediators by activated macrophages and reduced lethality in lipopolysaccharide (LPS)-induced endotoxin shock.		Immunology/Inflammation related
T7518	Deoxycytidine triphosphate trisodium salt	2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI	Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , Endogenous Metabolite , Antibiotic
	Deoxycytidine triphosphate trisodium salt (2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI) contributes to antibiotic lethality in stationary-phase mycobacteria.
TP1828	N-Acetyl-Ser-Asp-Lys-Pro		RAAS
	Acetyl Ser-Asp-Lys-Pro is formed in bone marrow cells by enzymatic processing of thymosin β4. It inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethalit...		RAAS
T39452	PIP4K-IN-a131	PIP4K-IN-a131
	PIP4K-IN-a131 is a selective inhibitor of PIP4K lipid kinases, demonstrating IC50 values of 1.9 μM for PIP4K2A and 0.6 μM for PIP4Ks. It exhibits cancer-selective lethality by simultaneously blocking the lipid kinase PIP...
T27050	CM-10-18	CM-1018
	CM-10-18 is a potent inhibitor of ER α-glucosidase. CM-10-18 demonstrated superior in vitro antiviral activity against representative viruses from four viral families causing hemorrhagic fever. CM-10-18 efficiently prote...
T78032	Endotoxin inhibitor TFA
	Endotoxin Inhibitor TFA is a synthetic peptide that exhibits high-affinity binding to lipid A, effectively detoxifying LPS and impeding LPS-induced cytokine release in vivo. It also suppresses the febrile response to LPS...
T63945	Antitubercular agent-19
	Antitubercular agent-19 is an antitubercular agent. antitubercular agent-19 showed good antitubercular effects against MTB H37Rv and MDR-MTB (MIC <0.016 μg/ml). antitubercular agent-19 showed low cytotoxicity and relativ...
T78959	ATR-IN-23		ATM/ATR
	ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility ...		ATM/ATR
T80226	R8 Bid BH3
	r8 Bid BH3, a biologically active peptide, is a pro-apoptotic member of the "BH3-only" subset within the BCL-2 family proteins, pivotal in regulating apoptosis. This compound exhibits lethality towards Bcl-2-expressing h...
T35517	4-deoxy Nivalenol-13C15	4-deoxy Nivalenol-13C15
	4-deoxy Nivalenol-13C15is intended for use as an internal standard for the quantification of 4-deoxy nivalenol by GC- or LC-MS. 4-deoxy Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It binds to e...
T80528	Ssm spooky toxin	SsTx Toxin	Potassium Channel
	Ssm Spooky Toxin, derived from Scolopendra mutilans, exhibits potent lethality affecting both hematological and respiratory systems primarily through the inhibition of KCNQ (voltage-gated potassium channel family 7) chan...		Potassium Channel
T36055	Nitisinone-13C6	Nitisinone-13C6
	Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyr...
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectiv...
T35515	3-Acetyldeoxy Nivalenol-13C17	3-Acetyldeoxy Nivalenol-13C17
	3-Acetyldeoxy nivalenol-13C17is intended for use as an internal standard for the quantification of 3-acetyldeoxy nivalenol by GC- or LC-MS. 3-Acetyldeoxy nivalenol is a mycotoxin that has been found inF. graminearum.1In ...
T35520	Aflatoxin G1-13C17	Aflatoxin G1-13C17
	Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to duckli...
T36703	CAY10760
	CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 μM in a cell-free competitive ELISA).1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing Bx...