leishmaniasis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN4660	Niranthin		Anti-infection , HBV , PAFR , Topoisomerase
	Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. N...		Anti-infection , HBV , PAFR , Topoisomerase
T12137	N-(2-Hydroxypropyl)methacrylamide		Parasite
	N-(2-Hydroxypropyl)methacrylamide is used in the synthesis of copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis.		Parasite
T1104	Paromomycin Sulfate	Aminosidine sulfate,Paromomycin sulfate salt	Antibacterial , Antibiotic , Parasite
	Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed...		Antibacterial , Antibiotic , Parasite
T0891	Dapsone	DDS,4,4‘-Sulfonyldianiline,Bis(4-aminophenyl) sulfone,Sulphadione,4,4'-Diaminodiphenylsulfone,4-Aminophenyl sulfone	Reactive Oxygen Species , Antibacterial , Antibiotic , Parasite
	Dapsone (Sulphadione) has activity against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.
T39746	DNDI-6148
	DNDI-6148 is a novel preclinical candidate for the treatment of visceral leishmaniasis.
T0033	Miltefosine	HePC,Hexadecyl phosphocholine	Akt , HIV Protease , PKC
	Miltefosine (HePC) is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medical agents produce some potency against visceral or cutaneou...		Akt , HIV Protease , PKC
T39214L	LXE408 fumarate	LXE408 fumarate (1799330-15-6 Free base)	Proteasome
	LXE408 fumarate is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 fumarate has an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. LXE408 fuma...		Proteasome
T29991	Aminoquinol triphosphate	Aminochinol triphosphate
	Aminoquinol triphosphate may be useful in the treatment of acute necrotising cutaneous leishmaniasis.
T23783	Benzoxonium chloride	Bradophen,Bialcol,D 301,D301,Cohortan
	Benzoxonium chloride, The topical treatment of anthroponotic cutaneous leishmaniasis with the tincture of thioxolone plus benzoxonium chloride (Thio-Ben) along with cryotherapy.
T29990	Aminoquinol diphosphate
	Aminoquinol diphosphate may be useful in the treatment of acute necrotising cutaneous leishmaniasis.
TN4470	Lyoniside		Antifection
	Lyoniside and saracoside are cytotoxic to promastigotes and intracellular amastigotes, they demonstrate strong anti-leishmanial efficacies in BALB/c mice model of leishmaniasis, suggests that these two compounds potentia...		Antifection
T39214	LXE408	LXE408
	LXE408 is an orally active, kinetoplastid-selective proteasome inhibitor, exhibiting non-competitive inhibitory effects. It demonstrates an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovan...
T62362	GNF6702
	GNF6702 is a selective inhibitor of the kinetoplastid proteasome and has been shown to be effective against parasites in mouse models of leishmaniasis, Chagas disease and human African trypanosomiasis.
T64056	Trypanothione synthetase-IN-4
	Trypanothione synthetase-IN-4 is a L. infantumTryS inhibitor whose activity is dependent on the concentration of the polyamine substrate. trypanothione synthetase-IN-4 exhibits a strong anti-leishmanicidal effect (EC50: ...
TN3568	Calceolarioside A		Calcium Channel , Antifection
	Calceolarioside A shows potent activity against visceral leishmaniasis. It can induce a dose-related aggregant effect on rabbit platelets, which may be partly related to a calcium-dependent mechanism. Calceolarioside A a...		Calcium Channel , Antifection
T60836	PT4
	PT4 is a treatment agent for Cutaneous leishmaniasis (CL). PT4 decreases of mitochondrial membrane potential and increases reactive oxygen species production, therefore leads to parasite death. PT4 is effective against b...
T65387	Paromomycin, sulfate (1:1)
	Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven...