hypercholesterolemia — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21383	D-Thyroxine	Dethyrona,Detyroxin,Dextroid,Dextrothyroxine;Biotirmone,Dextroxin,Biotirmone,Debetrol,Dextrothyroxine	Others
	D-Thyroxine (Dextroxin) could lower cholesterol and also increases hepatic lipase which in turn improves utilization of triglycerides, leading to improve apolipoprotein E cholesterol particles.		Others
T9920	Evolocumab		Others
	Evolocumab is a human IgG2 monoclonal antibody that binds to human PCSK9 Proprotein Convertase Subtilisin Kexin Type 9).		Others
T31611	Eldacimibe	WAY-ACA-147,UNII-4PBL76O2G8,ANA 147,ACA 147	Acyltransferase
	Eldacimibe (WAY-ACA-147) is an ACAT2 inhibitor for the treatment of cardiovascular disease and endocrine and metabolic disorders, study of atherosclerosis and hypercholesterolemia.		Acyltransferase
T4509	Inositol nicotinate	Inositol niacinate,Hexanicotol,Myo-Inositol hexanicotinate,Mesotal,Dilexpal,Inositol hexanicotinate	Others
	Inositol nicotinate (Mesotal) has the effect of lowering cholesterol and expanding peripheral blood vessels for hypercholesterolemia and atherosclerosis.		Others
T25276	Crilvastatin	PMD387,PMD 387,PMD-387	HMG-CoA Reductase
	Crilvastatin (PMD 387) is a novel non-competitive hydroxymethylglutaryl coenzyme A reductase inhibitor with cholesterol-lowering activity that inhibits cholesterol uptake in rats with hereditary hypercholesterolemia.		HMG-CoA Reductase
T2968	Hyodeoxycholic acid	NSC 60672,α-Hyodeoxycholic Acid,HDCA	FXR , Endogenous Metabolite , GPCR19
	Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.		FXR , Endogenous Metabolite , GPCR19
T27832	Lifibrol	U 83860,K-12148,K-12.148,U-83860,K12148	Lipid
	Lifibrol (U-83860) is an inhibitor of cholesterol synthesis.Lifibrol has anticholesterol and hypolipidemic properties and promotes the conversion of LDL Apo B-100 in patients with hypercholesterolemia and mixed hyperlipi...		Lipid
T17056	Tetrahydrobiopterin	Sapropterin,BH4,(Rac)-Sapropterin	NOS , Endogenous Metabolite
	Tetrahydrobiopterin (BH4) is a cofactor for aromatic amino acid hydroxylases and an essential cofactor for nitric oxide synthase (NOS), which is used in the study of endothelial dysfunction such as hypertension, hypercho...		NOS , Endogenous Metabolite
T76739	Bococizumab	RN316,PF-04950615	Others
	Bococizumab(PF-04950615) is a humanized mAb against PCSK9 and an inhibitor of the synthesis of PCSK9 in the liver that reduces the amount of low-density lipoprotein cholesterol (LDL-C) in the blood.Bococizumab is used to...		Others
T76941	Carotuximab	DE-122,TRC105	TGF-beta/Smad , Immunology/Inflammation related
	Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab h...		TGF-beta/Smad , Immunology/Inflammation related
T3874	Diosgenin glucoside	Disogluside,Trillin	Apoptosis , Others , Autophagy
	Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis. Significant inhibition of Diosgenin glucoside synthesis an...		Apoptosis , Others , Autophagy
T30977	Clofibride
	Clofibrin is a kind of hypolipidemic drug, which can reduce Hypertriglyceride and hypercholesterolemia.
T27565	Hyzetimibe	HS25,HS 25,HS-25
	Hyzetimibe, a cholesterol absorption blocker, is used potentially for the treatment of hypercholesterolemia.
T28440	PPD 10558	PPD-10558,RBx10558,RBx-10558,PPD10558,RBx 10558
	PPD 10558, a HMG-CoA reductase inhibitor, is used potentially for treatment of primary hypercholesterolemia.
T26182	Seladelpar lysine	MBX-8025 lysine dihydrate,MBX-8025 Lysine,MBX 8025 Lysine MBX8025 Lysine
	Seladelpar lysine, a selective PPAR-δ agonist, is used for the therapy of Homozygous Familial Hypercholesterolemia (HoFH).
T27245	(RS)-Eflucimibe	F12511,L-0081,F-12511,L0081
	Eflucimibe is an ACAT inhibitor. Eflucimibe regulates endogenous hypercholesterolemia in a synergistic manner in New Zealand rabbits fed a casein-enriched diet. In vivo, orally administered Eflucimibe displayed high pote...
T81918	Lodelcizumab
	Lodelcizumab, a monoclonal antibody, is utilized in the study of hypercholesterolemia [1].
T61430	S-2E
	S-2E is a compound that functions as an orally active, noncompetitive inhibitor of both HMG-CoA reductase and acetyl-CoA carboxylase. It exhibits an anti-hyperlipidemic action, making it suitable for studying conditions ...
T79052	PCSK9-IN-16
	PCSK9-IN-16, holds potential for research into hypercholesterolemia and other cardiovascular diseases [1].
T35724	4-hydroxy Atorvastatin (calcium salt)
	4-hydroxy Atorvastatin is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. Atorvastatin is metabolized by ...