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Tetrahydrobiopterin

Catalog No. T17056 CAS 17528-72-2

Synonyms: Sapropterin, BH4, (Rac)-Sapropterin

Tetrahydrobiopterin (BH4) is a cofactor for aromatic amino acid hydroxylases and an essential cofactor for nitric oxide synthase (NOS), which is used in the study of endothelial dysfunction such as hypertension, hypercholesterolemia, and diabetes.

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Tetrahydrobiopterin, CAS 17528-72-2

Pack Size	Availability	Price/USD
2 mg	In stock	$ 106.00
5 mg	In stock	$ 175.00
1 mL * 10 mM (in DMSO)	In stock	$ 189.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tetrahydrobiopterin (BH4) is a cofactor for aromatic amino acid hydroxylases and an essential cofactor for nitric oxide synthase (NOS), which is used in the study of endothelial dysfunction such as hypertension, hypercholesterolemia, and diabetes.
In vitro	Microglia cultures under hyperoxic conditions were supplemented with or without Tetrahydrobiopterin (100 μM). Exposure of microglia to hyperoxia-induced oxidative stress for 24 h showed a significant increase in TSP-1 mRNA expression and protein compared with normoxia (21% O2). Tetrahydrobiopterin supplementation significantly prevents hyperoxia-induced microglial activation and prevents microvascular damage in choroidal explants by reducing Iba-1 and TSP-1 expression.[1]
In vivo	To assess the levels of tetrahydrobiopterin in the retina, three to five retinal pools were collected from WT and HPH-1 mice at postnatal ages 7, 14, and 22 years and evaluated by LC-MS/MS. LC-MS/MS analysis confirmed that the concentration level of tetrahydrobiopterin in the retinal tissue of HPH-1 mice was significantly reduced by approximately 90% compared with WT groups P7, P14, and P22, respectively.[1]

Synonyms	Sapropterin, BH4, (Rac)-Sapropterin
Molecular Weight	241.25
Formula	C9H15N5O3
CAS No.	17528-72-2

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (165.80 mM), Sonication is recommended.

References and Literature

1. Rivera JC, et al. Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina. J Neuroinflammation. 2017 Sep 6;14(1):181.

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Keywords

Tetrahydrobiopterin 17528-72-2 Immunology/Inflammation Metabolism NOS Endogenous Metabolite BH 4 Sapropterin BH4 (Rac)-Sapropterin BH-4 inhibitor inhibit

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