hydroxylation — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7692	2,4-DPD		HIF
	2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)		HIF
T11847L	Liarozole	R75251 dihydrochloride	P450 , Retinoid Receptor
	Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1...		P450 , Retinoid Receptor
T3S0804	Worenine	Worenin	Others
	Worenine (Worenin) is used in the a flurophore switched probe which aids in correction of an abasic site (AP site) caused by the removal of a damaged base in DNA.		Others
T9624	Iron chloride hexahydrate
	iron chloride hexahydrate promoted selective hydroxylation and chlorination of benzyl ketone derivatives for the construction of hetero-quaternary scaffolds.
T3696	Polygalaxanthone III		Others , P450
	Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.		Others , P450
T21653	1,4-DPCA		HIF/HIF Prolyl-Hydroxylase
	1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).		HIF/HIF Prolyl-Hydroxylase
T2S2211	Tenuifoliside C		Dehydrogenase
	Tenuifoliside C, isolated from polygala tenuifolia willd, is a target lactate dehydrogenase inhibitor. It significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1[1].		Dehydrogenase
T3397	Epmedin C	Baohuoside-VI,Epimedin C	Others
	Epmedin C (Baohuoside-VI) was metabolized via desugarization, dehydrogenation, hydrogenation, dehydroxylation, hydroxylation, demethylation and glucuronidation pathways in vivo. It has potential activity against osteopor...		Others
T3881	Vaccarin		Integrin , Akt , PERK , AMPK
	Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation.		Integrin , Akt , PERK , AMPK
T3818	Fraxinol		Others , P450
	Fraxinol is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of 5, 7-dimethoxy-2h-chromen-2-one. It is generated by cyp1a2, cyp2a6, cyp2b6, cyp2c9, cyp2c19, and cyp2e1 enzymes via an...		Others , P450
TQ0121	VH-298		Others , HIF , Ligand for E3 Ligase
	VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by P...		Others , HIF , Ligand for E3 Ligase
T1055	Ifosfamide	NSC109724,Isophosphamide	DNA Alkylator/Crosslinker , DNA/RNA Synthesis
	Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic acti...		DNA Alkylator/Crosslinker , DNA/RNA Synthesis
T4A2458	Resibufogenin	Bufogenin,Recibufogenin	Others
	1. Resibufogenin (Bufogenin) is a cytotoxic steroid isolated from the Chinese drug ChanSu. 2. Resibufogenin can inhibit rectifier potassium current ( I K ) and transient potassium current ( I A ), it has pathological eff...		Others
T11277	FG 7142	ZK 39106,LSU-65	GABA Receptor
	FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cereb...		GABA Receptor
T33370	Metyrapol	SU 5236,SU-5236,SU5236
	Metyrapol is a competitive inhibitor of 11-deoxycorticosterone hydroxylation by 11β-hydroxylase.
T32743	Licodione
	Licodione is a Cytochrome P450 Monooxygenase Catalyzing 2-Hydroxylation of 5-Deoxyflavanone.
T19394	L-hydroxylysine dihydrochloride	(2S,5R)-5-Hydroxylysine dihydrochloride	Others
	L-hydroxylysine dihydrochloride , is formed by posttranslational hydroxylation of some lysine residues. It is an amino acid, is exclusive to collagen protein.		Others
T19610	(24S)-24,25-Dihydroxyvitamin D3	(24S)-24,25-Dihydroxycholecalciferol	Others
	(24S)-24,25-Dihydroxyvitamin D3 undergoes various levels of hydroxylation to form active vitamin D3 analogs.		Others
T19773	Diethyl bipy55'DC
	Diethyl bipy55'DC inhibits CP4H activity in cultured cells. The stability of collagen relies on post-translational modifications, the most prevalent being the hydroxylation of collagen strands by collagen prolyl 4-hydrox...
TMA2106	(-)-Sparteine		P450
	Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 protein in the livers of poor metabolizers.		P450