Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 76.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 328.00 | |
25 mg | In stock | $ 558.00 | |
50 mg | In stock | $ 788.00 | |
100 mg | In stock | $ 1,120.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 226.00 |
Description | Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders. |
Targets&IC50 | Cytochrome P450 (CYP26):7 μM (IC50) |
In vitro | Liarozole inhibits 17a-hydroxylase activity in bovine adrenal microsomes (IC50=0.15 μM) [1]. Liarozole has modest inhibitory activity on cholesterol synthesis in human hepatoma cells(IC50=5 μM)[1].Liarozole inhibits the metabolism of retinoic acid to more polar metabolites in hamster liver microsomes (IC50=2.2 μM), rat liver homogenate (IC50=0.14 μM), dunning prostate cancer homogenate (IC50=0.26 μM) and MCF-7 human breast cancer cells (almost complete block at 10μM) [1]. |
Synonyms | R75251 dihydrochloride |
Molecular Weight | 308.76 |
Formula | C17H13ClN4 |
CAS No. | 115575-11-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (178.13 mM)
You can also refer to dose conversion for different animals. More
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Liarozole 115575-11-6 Metabolism Retinoid Receptor P450 Retinoic acid receptors Mesenchymal RAR/RXR R 75251 CYPs Retinoid X receptors R75251 dihydrochloride R75251 Imidazole Ovariectomized R-75251 R75251 Dihydrochloride MCF-7 R-75251 Dihydrochloride Cytochrome P450 Inhibitor inhibit SCID R 75251 Dihydrochloride Hydroxylation inhibitor