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Liarozole

Catalog No. T11847L   CAS 115575-11-6
Synonyms: R75251 dihydrochloride

Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Liarozole Chemical Structure
Liarozole, CAS 115575-11-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 76.00
5 mg In stock $ 198.00
10 mg In stock $ 328.00
25 mg In stock $ 558.00
50 mg In stock $ 788.00
100 mg In stock $ 1,120.00
1 mL * 10 mM (in DMSO) In stock $ 226.00
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Purity: 99.38%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.
Targets&IC50 Cytochrome P450 (CYP26):7 μM (IC50)
In vitro Liarozole inhibits 17a-hydroxylase activity in bovine adrenal microsomes (IC50=0.15 μM) [1]. Liarozole has modest inhibitory activity on cholesterol synthesis in human hepatoma cells(IC50=5 μM)[1].Liarozole inhibits the metabolism of retinoic acid to more polar metabolites in hamster liver microsomes (IC50=2.2 μM), rat liver homogenate (IC50=0.14 μM), dunning prostate cancer homogenate (IC50=0.26 μM) and MCF-7 human breast cancer cells (almost complete block at 10μM) [1].
Synonyms R75251 dihydrochloride
Molecular Weight 308.76
Formula C17H13ClN4
CAS No. 115575-11-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (178.13 mM)

TargetMolReferences and Literature

1. Bryson HM, et al. Liarozole. Drugs Aging. 1996 Dec;9(6):478-84; discussion 485.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Orally Active Compound Library Anti-Cancer Compound Library Anti-Metabolism Disease Compound Library Anti-Aging Compound Library Anti-Prostate Cancer Compound Library Human Metabolite Library

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Keywords

Liarozole 115575-11-6 Metabolism Retinoid Receptor P450 Retinoic acid receptors Mesenchymal RAR/RXR R 75251 CYPs Retinoid X receptors R75251 dihydrochloride R75251 Imidazole Ovariectomized R-75251 R75251 Dihydrochloride MCF-7 R-75251 Dihydrochloride Cytochrome P450 Inhibitor inhibit SCID R 75251 Dihydrochloride Hydroxylation inhibitor

 

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