helicase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T72107	Werner syndrome RecQ helicase-IN-1		DNA/RNA Synthesis
	Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.		DNA/RNA Synthesis
T72108	Werner syndrome RecQ helicase-IN-2
	Werner syndrome RecQ helicase-IN-2 (example 57), a potent inhibitor of the Werner syndrome RecQ DNA helicase enzyme (WRN), holds potential for use in cancer research.
T22980	MIRA-1	p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor	DNA/RNA Synthesis , p53
	MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM.		DNA/RNA Synthesis , p53
T72109	Werner syndrome RecQ helicase-IN-3
	Werner syndrome RecQ helicase-IN-3, a potent and orally active inhibitor of Werner syndrome RecQ helicase (WRN), exhibits anticancer and antiproliferative activities with an IC50 value of 0.06 µM.
T72110	Werner syndrome RecQ helicase-IN-4
	Werner syndrome RecQ helicase-IN-4 is a potent, orally active inhibitor of Werner syndrome RecQ helicase (WRN) with an IC50 of 0.06 µM, exhibiting both antiproliferative and anticancer activities.
T9168	NSC 617145	NSC617145,NSC-617145	DNA/RNA Synthesis
	NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.		DNA/RNA Synthesis
T22282	Brr2-IN-3	Brr2 Inhibitor 9,Brr2 Inhibitor C9	Others
	Brr2-IN-3 (Brr2 Inhibitor C9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa (a group of progressive retinal degenerative disorders).		Others
T5413	ML216	CID-49852229	DNA/RNA Synthesis
	ML216 (CID-49852229) is a small molecule inhibitor of BLM helicase (IC50: 1.8 μM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s > 50 μM).		DNA/RNA Synthesis
T16961	Supinoxin	RX-5902	Apoptosis , DNA/RNA Synthesis
	Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and inhibits the growth of TNBC cancer cell lines (IC50...		Apoptosis , DNA/RNA Synthesis
T2504	Pritelivir	BAY 57-1293,AIC316	DNA/RNA Synthesis , HSV
	Pritelivir (BAY 57-1293) (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).		DNA/RNA Synthesis , HSV
T4226	Amenamevir	ASP2151	DNA/RNA Synthesis , HSV
	Amenamevir (ASP2151) is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mL).		DNA/RNA Synthesis , HSV
T40823	NCGC00029283		DNA/RNA Synthesis
	NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom synd...		DNA/RNA Synthesis
T19073	Tris(4-aminophenyl)methane	Leucopararosaniline	HCV Protease
	Tris(4-aminophenyl)methane (Leucopararosaniline), a triphenylmethane dye, is a weak HCV helicase inhibitor.		HCV Protease
TJS0368	4-Phenyl-7,8-dihydroxycoumarin	7,8-Dihydroxy-4-Phenyl-2H-Chromen-2-One,7,8-Dihydroxy-4-phenylcoumarin	Others
	4-Phenyl-7,8-dihydroxycoumarin (7,8-Dihydroxy-4-phenylcoumarin) inhibits the activity of Staphylococcus aureus DNA helicase		Others
T2275	YK-4-279		Apoptosis , DNA/RNA Synthesis
	YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1.		Apoptosis , DNA/RNA Synthesis
T9678	ML328		Others
	ML328 is a potent and selective inhibitor of bacterial AddAB(IC50 = 1.0 μM) and RecBCD(IC50 = 4.8 μM) helicase-nucleases.		Others
T82568	DHX9-IN-2		DNA/RNA Synthesis
	DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.		DNA/RNA Synthesis
T6970	RK33	RK-33,RK 33	COX
	RK33 (RK 33) is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.		COX
T9679	N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)pyrazine-2-carboxamide		Antibacterial
	N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)pyrazine-2-carboxamide exhibit an inhibitory effect on bacterial DNA helicases, nucleases, or helicase-nuclease enzyme complexes, such as, for example, one or more enzym...		Antibacterial
T15146	DNA2 inhibitor C5		Others
	DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress and it also is a competitive and specific inhibitor of DNA2 nuclease activity (IC50: 20 μM)...		Others