Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 70.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 176.00 | |
50 mg | In stock | $ 253.00 | |
100 mg | In stock | $ 397.00 | |
500 mg | In stock | $ 936.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 77.00 |
Description | NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. |
In vitro | NSC 617145 inhibits growth of HeLa cells via formation of DNA double strand breaks (DSBs) and induction of apoptosis in a WRN helicase-dependent manner. NSC 617145 also acts synergistically with mitomycin C to inhibit growth as well as induce DSBs and chromosomal abnormalities in Fanconia-anemia deficient (FA-D2-/-) cells. |
Synonyms | NSC617145, NSC-617145 |
Molecular Weight | 400.04 |
Formula | C13H10Cl4N2O4 |
CAS No. | 203115-63-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/ml (15 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NSC 617145 203115-63-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis breaks NHEJ helicase NSC617145 DSB abnormalities WRN strand Rad51 chromosomal ATPase Inhibitor inhibit NSC-617145 double inhibitor