dihydrofolate — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15128	Dihydrofolic acid	7,8-Dihydrofolic acid,Dihydrofolate	Others
	Dihydrofolic acid (7,8-Dihydrofolic acid) is a folic acid derivative that produces tetrahydrofolic acid in the presence of dihydrofolic acid reductase.		Others
T3693	DHFR-IN-3	7-bromoquinazoline-2,4-diamine	Others
	DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.		Others
T6120	Pralatrexate	Folotyn,10-Propargyl-10-deazaaminopterin	Apoptosis , DHFR , Antifolate , TAM Receptor
	Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive act...		Apoptosis , DHFR , Antifolate , TAM Receptor
T1153	Trimethoprim	NIH 204,BW 56-72,NSC-106568	DHFR , DNA/RNA Synthesis , Antifolate , Antibacterial , Antibiotic
	Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Tra...
T20340	10-Formyldihydrofolate
	10-Formyldihydrofolate is a Methotrexate metabolite. It inhibits thymidylate synthetase and glycinamide ribotide transformylase.
T29460	5-Methyldihydrofolate
	5-Methyldihydrofolate is the primary biologically active form of folate used for DNA reproduction, the cysteine cycle, and the regulation of homocysteine.
T17257L	WR99210 hydrochloride(47326-86-3 free base)	WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine	Others
	WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mut...		Others
T24962	10-Formylfolic acid		DHFR
	10-Formylfolic acid is a novel and potent inhibitor of dihydrofolate reductase, which can be used in leukemia research.		DHFR
T19858	Brodimoprim		DHFR , Antibacterial
	Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR). Brodimoprim is also a long-acting broad-spectrum antibacterial agent characterized by a good pharmacokinetic profile.		DHFR , Antibacterial
T0849	Pyrimethamine	Pirimecidan,RP 4753,Pirimetamin	DHFR , Antifolate , Parasite
	Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.		DHFR , Antifolate , Parasite
TQ0113	Iclaprim	AR-100	Antibacterial , Antibiotic
	Iclaprim (AR-100) is a novel specific bacterial Dihydrofolate inhibitor. It can inhibit the growth of S. aureus (MIC90: 0.06 μg/mL).		Antibacterial , Antibiotic
T25886	Methotrexate Diglutamate	NSC-269401,NSC 269401,NSC269401	DHFR
	Methotrexate Diglutamate Small molecule compound present in the liver that acts as a partially purified human dihydrofolate reductase inhibitor.		DHFR
T61486	DHFR-IN-4		DHFR
	DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer.		DHFR
T24644	Piritrexim	BW 301U	DHFR
	Piritrexim (BW 301U) is an orally available fat-soluble dihydrofolate reductase inhibitor with pulmonary toxicity used in the study of uroepithelial carcinoma and metastatic breast cancer.		DHFR
T7730	Aminopterin	APGA,4-Aminofolic acid	Antifolate
	Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase		Antifolate
T1485	Methotrexate	NCI-C04671,WR19039,Amethopterin,CL14377	Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
	Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v...		Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
T5420	Cycloguanil hydrochloride	Chloroguanide Triazine	Parasite , Drug Metabolite
	Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, r...		Parasite , Drug Metabolite
T36692	Fanotaprim		DHFR
	Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio o...		DHFR
T4382	Proguanil hydrochloride	Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil	Others , Dehydrogenase , DNA/RNA Synthesis , Antifolate , Parasite
	Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine ...
T20339	7-Hydroxymethotrexate	NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962	Drug Metabolite
	7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibitin...		Drug Metabolite