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10-Formyldihydrofolate

Catalog No. T20340 CAS 28459-40-7

10-Formyldihydrofolate is a Methotrexate metabolite. It inhibits thymidylate synthetase and glycinamide ribotide transformylase.

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10-Formyldihydrofolate Chemical Structure

10-Formyldihydrofolate, CAS 28459-40-7

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	$ 352.00
50 mg	Inquiry	$ 1,969.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

10-Formyldihydrofolate is a Methotrexate metabolite. It inhibits thymidylate synthetase and glycinamide ribotide transformylase.

Molecular Weight	471.43
Formula	C20H21N7O7
CAS No.	28459-40-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Sah S, Shah RA, Govindan A, Varada R, Rex K, Varshney U. Utilisation of 10-formyldihydrofolate as substrate by dihydrofolate reductase (DHFR) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) tranformylase/IMP cyclohydrolase (PurH) in Escherichia coli. Microbiology. 2018 May 25. doi: 10.1099/mic.0.000671. [Epub ahead of print] PubMed PMID: 29799386. 2. Naz N, Jimenez AR, Sanjuan-Vilaplana A, Gurney M, Miyan J. Neonatal hydrocephalus is a result of a block in folate handling and metabolism involving 10-formyltetrahydrofolate dehydrogenase. J Neurochem. 2016 Aug;138(4):610-23. doi: 10.1111/jnc.13686. Epub 2016 Jul 25. PubMed PMID: 27294849. 3. Baggott JE, Tamura T. Folate-Dependent Purine Nucleotide Biosynthesis in Humans. Adv Nutr. 2015 Sep 15;6(5):564-71. doi: 10.3945/an.115.008300. Print 2015 Sep. Review. PubMed PMID: 26374178; PubMed Central PMCID: PMC4561830. 4. Baggott JE, Tamura T. Evidence for the hypothesis that 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylase. Exp Biol Med (Maywood). 2010 Mar;235(3):271-7. doi: 10.1258/ebm.2009.009151. Review. PubMed PMID: 20404044.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

10-Formyldihydrofolate 28459-40-7 10Formyldihydrofolate 10 Formyldihydrofolate inhibitor inhibit

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