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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9080 | Plecanatide | Guanylate cyclase | |
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist. | |||
T0786 | Clidinium bromide | Ro 2-3773 | AChR |
Clidinium bromide (Ro 2-3773) , a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effect on the gastrointestinal tract. It can... | |||
T2542 | Prucalopride | R-93877 | 5-HT Receptor |
Prucalopride (R-93877) is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes. | |||
T20576 | Lactitol | NSC 231323,Lactit,D-Lactitol,NSC231323,NSC-231323,Lactosit Miruhen | Others |
Lactitol (Lactit) is a agent that acts on the gastrointestinal tract. | |||
T16083 | Mizagliflozin | GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base | SGLT |
Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca... | |||
T11852 | Linaclotide | Guanylate cyclase | |
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist. | |||
TMO2787 | Anthraquinone | dioxoanthracene,Anthradione,anthracenedione | Virus Protease |
Anthraquinone (Anthradione)s are the main active constituents in herbs often used to relieve constipation. | |||
T3355 | Naloxegol oxalate | NKTR-118,NKTR-118 oxalate,AZ 13337019,AZ-13337019 oxalate | P450 |
Naloxegol oxalate (NKTR-118) is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. | |||
T6307 | Lubiprostone | SPI-0211,RU-0211 | Chloride channel |
Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation. | |||
T2734 | Sennoside B | PDGFR | |
Sennoside B is an anthranoid. Anthranoid derivatives are used all over the world as a treatment for constipation. | |||
T11827 | Pradigastat | ANJ908,LCQ908-NXA,LCQ908A,LCQ-908 | Transferase |
Pradigastat (LCQ-908) is an orally active, potent and selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor for the treatment of constipation, which may be used in the study of obesity and diabetes. | |||
T1551 | Tegaserod maleate | HTF-919,SDZ-HTF-919 | 5-HT Receptor |
Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug ... | |||
T38507 | Renzapride | BRL 24924 | 5-HT Receptor |
Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS). | |||
T0299 | Lactitol monohydrate | D-Lactitol monohydrate | Others |
Lactitol monohydrate (D-Lactitol monohydrate) is a disaccharide analog of lactulose. It has been widely used to treat constipation and hepatic encephalopathy. | |||
T0799 | Lactulose | Duphalac,4-O-β-D-Galactopyranosyl-D-fructose,D-Lactulose,Lactulosum | Others |
Lactulose (Lactulosum) , a synthetic disaccharide , is used in the treatment of constipation and hepatic encephalopathy. | |||
T15209 | Elobixibat | AZD 7806,A 3309 | Others |
Elobixibat (A 3309) is an inhibitor of the ileal bile acid transporter (IC50: 0.13 nM, 0.53 nM, and 5.8 nM for mouse, human, and canine IBAT). Elobixibat can be used in studies about chronic idiopathic constipation. | |||
T28043L | Minesapride | 5-HT Receptor | |
Minesapride, a novel 5-hydroxytryptamine 4 (5-HT4) receptor partial agonist, is a potential gastrointestinal prokinetic agent for the treatment of irritable bowel syndrome with constipation. | |||
T6414 | Bisacodyl | Fenilaxan,Dulcolax,Brocalax | Others |
Bisacodyl (Fenilaxan) is a diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation. | |||
T0929 | Docusate sodium | Aerosol OT,Dioctyl sulfosuccinate sodium salt,Bis(2-ethylhexyl) sulfosuccinate sodium salt,Constonate | Opioid Receptor , HSV |
Docusate sodium (Aerosol OT) is an orally available, over-the-counter laxative and stool softener used to treat or prevent constipation. Docusate has not been linked to serum enzyme elevations during therapy or to clinic... | |||
T21422 | Methylnaltrexone bromide | Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728 | Opioid Receptor |
Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without af... |