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Search Results for " constipation "

20

Compounds

Cat No. Product Name Synonyms Targets
T9080 Plecanatide Guanylate cyclase
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
T0786 Clidinium bromide Ro 2-3773 AChR
Clidinium bromide (Ro 2-3773) , a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effect on the gastrointestinal tract. It can...
T2542 Prucalopride R-93877 5-HT Receptor
Prucalopride (R-93877) is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes.
T20576 Lactitol NSC 231323,Lactit,D-Lactitol,NSC231323,NSC-231323,Lactosit Miruhen Others
Lactitol (Lactit) is a agent that acts on the gastrointestinal tract.
T16083 Mizagliflozin GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base SGLT
Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca...
T11852 Linaclotide Guanylate cyclase
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist.
TMO2787 Anthraquinone dioxoanthracene,Anthradione,anthracenedione Virus Protease
Anthraquinone (Anthradione)s are the main active constituents in herbs often used to relieve constipation.
T3355 Naloxegol oxalate NKTR-118,NKTR-118 oxalate,AZ 13337019,AZ-13337019 oxalate P450
Naloxegol oxalate (NKTR-118) is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.
T6307 Lubiprostone SPI-0211,RU-0211 Chloride channel
Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.
T2734 Sennoside B PDGFR
Sennoside B is an anthranoid. Anthranoid derivatives are used all over the world as a treatment for constipation.
T11827 Pradigastat ANJ908,LCQ908-NXA,LCQ908A,LCQ-908 Transferase
Pradigastat (LCQ-908) is an orally active, potent and selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor for the treatment of constipation, which may be used in the study of obesity and diabetes.
T1551 Tegaserod maleate HTF-919,SDZ-HTF-919 5-HT Receptor
Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug ...
T38507 Renzapride BRL 24924 5-HT Receptor
Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS).
T0299 Lactitol monohydrate D-Lactitol monohydrate Others
Lactitol monohydrate (D-Lactitol monohydrate) is a disaccharide analog of lactulose. It has been widely used to treat constipation and hepatic encephalopathy.
T0799 Lactulose Duphalac,4-O-β-D-Galactopyranosyl-D-fructose,D-Lactulose,Lactulosum Others
Lactulose (Lactulosum) , a synthetic disaccharide , is used in the treatment of constipation and hepatic encephalopathy.
T15209 Elobixibat AZD 7806,A 3309 Others
Elobixibat (A 3309) is an inhibitor of the ileal bile acid transporter (IC50: 0.13 nM, 0.53 nM, and 5.8 nM for mouse, human, and canine IBAT). Elobixibat can be used in studies about chronic idiopathic constipation.
T28043L Minesapride 5-HT Receptor
Minesapride, a novel 5-hydroxytryptamine 4 (5-HT4) receptor partial agonist, is a potential gastrointestinal prokinetic agent for the treatment of irritable bowel syndrome with constipation.
T6414 Bisacodyl Fenilaxan,Dulcolax,Brocalax Others
Bisacodyl (Fenilaxan) is a diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation.
T0929 Docusate sodium Aerosol OT,Dioctyl sulfosuccinate sodium salt,Bis(2-ethylhexyl) sulfosuccinate sodium salt,Constonate Opioid Receptor , HSV
Docusate sodium (Aerosol OT) is an orally available, over-the-counter laxative and stool softener used to treat or prevent constipation. Docusate has not been linked to serum enzyme elevations during therapy or to clinic...
T21422 Methylnaltrexone bromide Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728 Opioid Receptor
Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without af...

Compounds

Plecanatide
T9080
Synonym:
Target: Guanylate cyclase
Clidinium bromide
T0786
Synonym: Ro 2-3773
Target: AChR
Prucalopride
T2542
Synonym: R-93877
Target: 5-HT Receptor
Lactitol
T20576
Synonym: NSC 231323,Lactit,D-Lactitol,NSC231323,NSC-231323,Lactosit Miruhen
Target: Others
Mizagliflozin
T16083
Synonym: GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base
Target: SGLT
Linaclotide
T11852
Synonym:
Target: Guanylate cyclase
Anthraquinone
TMO2787
Synonym: dioxoanthracene,Anthradione,anthracenedione
Target: Virus Protease
Naloxegol oxalate
T3355
Synonym: NKTR-118,NKTR-118 oxalate,AZ 13337019,AZ-13337019 oxalate
Target: P450
Lubiprostone
T6307
Synonym: SPI-0211,RU-0211
Target: Chloride channel
Sennoside B
T2734
Synonym:
Target: PDGFR
Pradigastat
T11827
Synonym: ANJ908,LCQ908-NXA,LCQ908A,LCQ-908
Target: Transferase
Tegaserod maleate
T1551
Synonym: HTF-919,SDZ-HTF-919
Target: 5-HT Receptor
Renzapride
T38507
Synonym: BRL 24924
Target: 5-HT Receptor
Lactitol monohydrate
T0299
Synonym: D-Lactitol monohydrate
Target: Others
Lactulose
T0799
Synonym: Duphalac,4-O-β-D-Galactopyranosyl-D-fructose,D-Lactulose,Lactulosum
Target: Others
Elobixibat
T15209
Synonym: AZD 7806,A 3309
Target: Others
Minesapride
T28043L
Synonym:
Target: 5-HT Receptor
Bisacodyl
T6414
Synonym: Fenilaxan,Dulcolax,Brocalax
Target: Others
Docusate sodium
T0929
Synonym: Aerosol OT,Dioctyl sulfosuccinate sodium salt,Bis(2-ethylhexyl) sulfosuccinate sodium salt,Constonate
Target: Opioid Receptor, HSV
Methylnaltrexone bromide
T21422
Synonym: Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728
Target: Opioid Receptor
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