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Mizagliflozin

Name: Mizagliflozin
Brand: TargetMol
SKU: T16083
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16083Cas No. 666843-10-3

Alias KGA-3235 free base, GSK-1614235 free base, DSP-3235 free base

Mizagliflozin is an orally active, selective SGLT1 inhibitor with a Ki value of 27 nM for human SGLT1. Mizagliflozin is 303 times more selective for SGLT1 than for SGLT2. Mizagliflozin is an anti-diabetic drug that can improve postprandial blood sugar fluctuations and may have the potential to improve chronic constipation.

Mizagliflozin

🥰Excellent

Purity: 99.67%

Catalog No. T16083Alias KGA-3235 free base, GSK-1614235 free base, DSP-3235 free baseCas No. 666843-10-3

Pack Size	Price	Availability
1 mg	$64	In Stock
2 mg	$93	In Stock
5 mg	$155	In Stock
10 mg	$248	In Stock
25 mg	$492	In Stock
50 mg	$713	In Stock
100 mg	$987	In Stock
200 mg	$1,380	In Stock
1 mL x 10 mM (in DMSO)	$193	In Stock

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Purity:99.67%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Mizagliflozin is an orally active, selective SGLT1 inhibitor with a Ki value of 27 nM for human SGLT1. Mizagliflozin is 303 times more selective for SGLT1 than for SGLT2. Mizagliflozin is an anti-diabetic drug that can improve postprandial blood sugar fluctuations and may have the potential to improve chronic constipation.
Targets&IC50	SGLT2 (human):8170 nM(ki), SGLT1 (human):(ki)27 nM
In vivo	METHODS: Mizagliflozin (GSK-1614235 free base) (0.3 mg/kg, intravenous administration) and oral administration (3 mg/kg, oral administration) were administered to rats to study its pharmacokinetics and metabolite profile. RESULTS Mizagliflozin had different half-lives in rats (0.23 and 1.14 hours, respectively) depending on the administration route; the absolute bioavailability was only 0.02%; after oral administration, Mizagliflozin was mainly metabolized to its aglycone KP232 in the intestine. [2]
Synonyms	KGA-3235 free base, GSK-1614235 free base, DSP-3235 free base

Chemical Properties

Molecular Weight	564.67
Formula	C₂₈H₄₄N₄O₈
Cas No.	666843-10-3
Smiles	CC(C)c1[nH]nc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(OCCCNCC(C)(C)C(N)=O)cc1C
Relative Density.	1.274 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: 250 mg/mL (442.74 mM), Sonication is recommended.

DMSO: 100 mg/mL (177.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Methanol

	1mg	5mg	10mg	50mg
1 mM	1.7709 mL	8.8547 mL	17.7095 mL	88.5473 mL
5 mM	0.3542 mL	1.7709 mL	3.5419 mL	17.7095 mL
10 mM	0.1771 mL	0.8855 mL	1.7709 mL	8.8547 mL
20 mM	0.0885 mL	0.4427 mL	0.8855 mL	4.4274 mL
50 mM	0.0354 mL	0.1771 mL	0.3542 mL	1.7709 mL
100 mM	0.0177 mL	0.0885 mL	0.1771 mL	0.8855 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc