analogue — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2377	Pilaralisib analogue	XL147 analogue,SAR245408	Apoptosis , DNA-PK , PI3K
	Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.		Apoptosis , DNA-PK , PI3K
T3576	CPI-455 analogue	CPI-455 analogue	Others
	CPI-455 analogue (CPI-455 analogue) is an analogue of CPI-455 which is a KDM5 inhibitor.		Others
T12444	Phentolamine Analogue 1		Adrenergic Receptor
	Phentolamine Analogue 1 is an analogue of phentolamine. Phentolamine is a nonselective antagonist of α-adrenergic.		Adrenergic Receptor
T7944	VPS34 inhibitor 1 (Compound 19, PIK-III analogue)	PIK-III analogue	PI3K
	VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)		PI3K
T1826	PI3K-IN-1	Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409	DNA-PK , PI3K
	PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.		DNA-PK , PI3K
T2647	IDO5L	INCB024360 analogue,INCB14943	IDO , Indoleamine 2,3-Dioxygenase (IDO)
	IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).		IDO , Indoleamine 2,3-Dioxygenase (IDO)
T3076	GLPG0634 analog	GLPG0634 analogue	Tyrosine Kinases , JAK
	GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.		Tyrosine Kinases , JAK
T6921	ONO-4059 analog	ONO-4059 analogue,ONO-WG-307,GS-4059 analog	Apoptosis , BTK
	ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.		Apoptosis , BTK
T6705	TIC10 Isomer	ONC201 isomer,TIC10 Analogue	Others
	TIC10 Isomer (ONC201 isomer) is an isomer of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improv...		Others
T68855	Hymenialdisine Analogue #1
	Hymenialdisine Analogue #1 is the indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3Β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micro...
T22633	CCT251545 analogue, Compound 51		Others
	CCT251545 analog is a potent and selective CDK8/19 inhibitor (IC50: 5.1 nM and 5.6 nM, respectively). Mediator complex-associated kinases CDK8 and CDK19 are involved in the regulation of multiple transcription pathways. ...		Others
T1806	IDO-IN-7	NLG919,Navoximod,NLG-919 analogue,GDC-0919	Indoleamine 2,3-Dioxygenase (IDO)
	IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.		Indoleamine 2,3-Dioxygenase (IDO)
T11393	GET73	Gamma hydroxybutyric acid analogue,GET 73	GluR
	GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.		GluR
T19616	D-phenylalanine analogue	(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid	Others
	(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid, a constrained phenylalanine (Phe) analogue, exhibits the capacity to adopt beta-bend and helical structures, facilitating a preferred side-chain orientation within th...		Others
T11935	Macitentan (n-butyl analogue)		Others
	Macitentan n-butyl analogue, a derivative of Macitentan, functions as an orally active dual antagonist targeting both endothelin ETA and ETB receptors. This compound shows promise for treating idiopathic pulmonary fibros...		Others
T74641	Rezivertinib analogue 1
	Rezivertinib analogue 1, a process impurity of osimertinib mesylate, serves as a research tool in the study of non-small cell lung cancer (NSCLC) [1].
T81993	Kadsurin A analogue-1
	Kadsurin A Analogue-1 (Compound 8), a lignan, can be extracted from Piper argyrophylum [1].
T11549	Helioxanthin 8-1	Helioxanthin analogue 8-1	Others
	Helioxanthin 8-1, an analogue of helioxanthin, exhibits significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 μM.		Others
TNU0045	β-D-Ribofuranose analogue 1
	Nucleoside Derivatives - 5-Modified pyrimidine nucleosides; Thio-nucleosides; Amino nucleosides; Protected nucleosides w/NH2/OH open
T19858	Brodimoprim		DHFR , Antibacterial
	Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR). Brodimoprim is also a long-acting broad-spectrum antibacterial agent characterized by a good pharmacokinetic profile.		DHFR , Antibacterial