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IDO-IN-7

Name: IDO-IN-7
Brand: TargetMol
SKU: T1806
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1806Cas No. 1402836-58-1

Alias NLG-919 analogue, NLG919, Navoximod, GDC-0919

IDO-IN-7 (NLG-919 analogue) is a potent inhibitor of the IDO (indoleamine-(2, 3)-dioxygenase) pathway.

IDO-IN-7

🥰Excellent

Purity: 99.9%

Catalog No. T1806Alias NLG-919 analogue, NLG919, Navoximod, GDC-0919Cas No. 1402836-58-1

IDO-IN-7 (NLG-919 analogue) is a potent inhibitor of the IDO (indoleamine-(2, 3)-dioxygenase) pathway.

Pack Size	Price	Availability
10 mg	$38	In Stock
25 mg	$68	In Stock
50 mg	$117	In Stock
100 mg	$195	In Stock
500 mg	$488	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.9%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	IDO-IN-7 (NLG-919 analogue) is a potent inhibitor of the IDO (indoleamine-(2, 3)-dioxygenase) pathway.
Targets&IC50	IDO:75 nM(EC50)
In vitro	In mice bearing B16F10 tumors, NLG919 significantly enhanced the antitumor response of pmel-1 resting cells to homologous hgp100 peptide and CpG-1826.
In vivo	NLG919 effectively blocks the IDO-induced suppression of T-cell responses, restoring T-cell activity (ED50=80 nM). In mouse dendritic cells (DCs) expressing IDO from tumor lymph nodes (ED50=120 nM), NLG919 abolishes the IDO-induced inhibition of antigen-specific T-cells (OT-1).
Synonyms	NLG-919 analogue, NLG919, Navoximod, GDC-0919

Chemical Properties

Molecular Weight	282.38
Formula	C₁₈H₂₂N₂O
Cas No.	1402836-58-1
Smiles	OC(CC1c2ccccc2-c2cncn12)C1CCCCC1
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 26 mg/mL (92.07 mM), Sonication is recommended.

DMSO: 45 mg/mL (159.36 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5413 mL	17.7066 mL	35.4133 mL	177.0664 mL
5 mM	0.7083 mL	3.5413 mL	7.0827 mL	35.4133 mL
10 mM	0.3541 mL	1.7707 mL	3.5413 mL	17.7066 mL
20 mM	0.1771 mL	0.8853 mL	1.7707 mL	8.8533 mL
50 mM	0.0708 mL	0.3541 mL	0.7083 mL	3.5413 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0354 mL	0.1771 mL	0.3541 mL	1.7707 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc