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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T61562 | CB1R Allosteric modulator 3 | cAMP , Cannabinoid Receptor | |
CB1R Allosteric modulator 3 is a potent CB1R modulator.CB1R Allosteric modulator 3 inhibits cAMP and β-Arrestin, and can be used for the study of obesity and nicotine addiction. | |||
T5456 | WNK-IN-11 | Allosteric WNK Kinase Inhibitor | Serine/threonin kinase |
WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM) | |||
T62016 | CB1R Allosteric modulator 1 | ||
CB1R Allosteric modulator 1 (compound 11) is a potent allosteric modulator of CB1R. CB1R Allosteric modulator 1 negatively affects the functional activity of orthosteric ligands (NAM) at CB1Rs. | |||
T61276 | CB1R Allosteric modulator 2 | ||
CB1R Allosteric modulator 2 (compound 18) is a potent allosteric modulator of the CB1R receptor. It exhibits negative modulation of the functional activity of orthosteric ligands (NAM) at CB1Rs, as demonstrated in previo... | |||
T61371 | CB1R Allosteric modulator 4 | ||
CB1R Allosteric modulator 4 is an effective and positive modulator of cannabinoid type-1 (CB1R), exhibiting significant biological activity. This compound inhibits the production of cAMP and demonstrates strong β-arresti... | |||
T64096 | Integrase-LEDGF/p75 allosteric inhibitor 1 | ||
Integrase-LEDGF/p75 allosteric inhibitor 1 is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. It inhibits HIV-1 DNA integration and exhibits antiviral effects, acting on the HIV-1 recombinant mo... | |||
T22641 | CDPPB | GluR | |
CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5). | |||
T21781 | A-286982 | Integrin | |
A 286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1. | |||
T3464 | PHCCC | (-) PHCCC | GluR |
PHCCC ((-) PHCCC) is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mGluR8. | |||
T22703 | CYM-5520 | CYM 5520 | S1P Receptor , LPL Receptor |
CYM-5520 is a noncompetitive allosteric agonist of S1P2 | |||
T8868 | 4BP-TQS | AChR | |
4BP-TQS is an allosteric agonist of α7 nAChRs. | |||
T9884 | EN523 | Others | |
EN523 targets non-catalytic allosteric cysteine C23 in K48 ubiquitin-specific deuquitinase OTUB1. | |||
T4573 | Cyclothiazide | GluR | |
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M). | |||
T23515 | VU-29 | VU 29 | GluR |
VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM). | |||
T21747 | VU0483605 | GluR | |
VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively. | |||
T22027 | AH-7614 | AH 7614 | GPR |
AH-7614 (AH 7614) is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist. | |||
T9238 | KI-7 | Adenosine Receptor | |
KI-7 is an adenosine A2B receptor positive allosteric modulator. | |||
T8642 | 4-CMTB | GPR | |
4-CMTB is a selective agonist of FFA2 and GPR43.It also is a positive allosteric modulator (pEC50=6.38). | |||
T22711 | DCB | 3,3'-dichlorobenzaldazine | Others , GluR |
DCB (3,3'-dichlorobenzaldazine) is an allosteric ligand for mGluR5 and shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB). DCB blocks the positive allosteric regulation of mGluRs with the help of ... | |||
T9466 | RTICBM-189 | Others | |
RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectivel... |