Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 84.00 | |
5 mg | In stock | $ 190.00 | |
10 mg | In stock | $ 312.00 | |
25 mg | In stock | $ 526.00 | |
50 mg | In stock | $ 759.00 | |
100 mg | In stock | $ 1,070.00 | |
500 mg | In stock | $ 2,130.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 209.00 |
Description | WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM) |
Targets&IC50 | WNK1:4 nM |
In vitro | WNK-IN-11 (compound 11) exhibits potent activity as demonstrated by an IC50 value of less than 2 μM in the OSR1 phosphorylation assay, coupled with reasonable water solubility and relatively high microsomal clearance. It operates through ATP noncompetitive inhibition. When assessed against an expansive panel of 440 human kinases at a concentration of 10 μM, which is 2500-fold higher than the enzyme's IC50 value, WNK-IN-11 demonstrates outstanding selectivity, displaying significant off-target inhibition only against a select few kinases, including BTK and the feline encephalitis virus-related (FER) kinase, none of which are associated with the regulation of blood pressure. This specificity underscores its potential as a precisely targeted therapeutic agent, likely attributed to its predicted allosteric mode of binding outside the conserved ATP-pocket region. |
Synonyms | Allosteric WNK Kinase Inhibitor |
Molecular Weight | 462.4 |
Formula | C21H21Cl2N5OS |
CAS No. | 2123489-30-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 150 mg/mL (324.39 mM)
You can also refer to dose conversion for different animals. More
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WNK-IN-11 2123489-30-3 Cell Cycle/Checkpoint Metabolism Serine/threonin kinase Threonine proteases inhibit WNKIN11 Serine proteases Serine endopeptidases Inhibitor Allosteric WNK Kinase Inhibitor Ser/Thr Protease WNK IN 11 inhibitor