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Search Results for " wnt "

20

Compounds

Cat No. Product Name Synonyms Targets
T2242 Wnt-C59 C59 Wnt/beta-catenin , Porcupine
Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.
T13345 Wnt pathway activator 2 Others , Wnt/beta-catenin
Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.
T17256 Wnt pathway activator 1 Wnt/beta-catenin
Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM. Wnt pathway activator 1 is a potent Wnt activator for the treatment of androgenetic alopecia (AGA).
T77502 Wnt pathway inhibitor 3 Wnt/beta-catenin , Adenylyl cyclase
Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies to ameliorate osteoarthritis in a mouse model of experimenta...
T41094 Wnt/β-catenin agonist 2 GSK-3 , Wnt/beta-catenin
Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist. Wnt/β-catenin agonist 2 can be used in the study of diseases related to signal transduction and is closely related to cancer inva...
T9988 Wnt/β-catenin agonist 3 Wnt/beta-catenin
Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.
T3144 BML-284 Wnt agonist 1 Wnt/beta-catenin
BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.
T77716 Wnt pathway inhibitor 4 Antibacterial
Wnt pathway inhibitor 4 is a small molecule antimicrobial agent with antibacterial and antiproliferative activity against cancer cells.
T60803 Wnt/β-catenin agonist 4 Wnt/beta-catenin
Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.
T4245 IWP-4 Inhibitor of Wnt Production-4 Wnt/beta-catenin
IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.
T8820 BML-284 hydrochloride BML-284 HCL,Wnt agonist 1 HCL Wnt/beta-catenin
BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.
T13344 Wnt/β-catenin agonist 1 Others
Wnt/β-catenin agonist 1 is an agonist of Wnt/β-catenin signalling pathway(EC50 of 0.27 μM).
T82235 HCA/Wnt/β-catenin-IN-1
hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8 nM, respectively. Additionally, this compound attenuates P-g...
T2618 LGK974 LGK 974,LGK-974,NVP-LGK974,WNT974 Porcupine
LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cel...
TL0008 Gigantol Wnt/beta-catenin , Glucosidase
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a...
T9810 TNIK-IN-5 Wnt/beta-catenin
TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.
T1716 Echinacoside Reactive Oxygen Species , Wnt/beta-catenin
Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neuroprotective, nitric oxide radical-scavenging and vasodilat...
T4302 ICRT3 Apoptosis , Wnt/beta-catenin
iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
T4486 ICRT 14 Wnt/beta-catenin
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
T38519 YB-0158 Wnt pathway inhibitor 2,YB-0158
YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a r...
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