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BML-284

Catalog No. T3144 CAS 853220-52-7

Synonyms: Wnt agonist 1

BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

BML-284, CAS 853220-52-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 55.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 143.00
50 mg	In stock	$ 266.00
100 mg	In stock	$ 450.00
200 mg	In stock	$ 648.00
500 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 99.91%

Purity: 99.66%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.
Targets&IC50	TCF-dependent transcriptional activity:700 nM (EC50)
In vitro	Wnt agonist 1 does not inhibit the activity of GSK-3β, and may be a useful tool in the study of physiological processes that involve the Wnt pathway. [1]
In vivo	In a Xenopus model, Wnt agonist 1 (10 μM) mimics the effects of Wnt at the whole-organism level, and affects Xenopus embryonic head specification. [1]

Synonyms	Wnt agonist 1
Molecular Weight	350.37
Formula	C19H18N4O3
CAS No.	853220-52-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 77 mg/mL (199.05 mM)

References and Literature

1. Angew Chem Int Ed Engl. 2005, 44(13), 1987-1990. 2. Chen B, Zhao Y, Han D, et al. Wnt1 inhibits vascular smooth muscle cell calcification by promoting ANKH expression[J]. Journal of Molecular and Cellular Cardiology. 2019. 3. Wang C, Peng R, Yuan X, et al. Cellular and molecular responses-mediated by DjMEK1/2 are necessary for planarian regeneration[J]. International Journal of Biological Macromolecules . 2020, 164: 3751-3761.

Citations

1. Wang C, Peng R, Yuan X, et al. Cellular and molecular responses-mediated by DjMEK1/2 are necessary for planarian regeneration. International Journal of Biological Macromolecules. 2020, 164: 3751-3761. 2. Chen B, Zhao Y, Han D, et al. Wnt1 inhibits vascular smooth muscle cell calcification by promoting ANKH expression. Journal of Molecular and Cellular Cardiology. 2019

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Anti-Fibrosis Compound Library Wnt/Hedgehog/Notch Compound Library Anti-Prostate Cancer Compound Library Target-Focused Phenotypic Screening Library Anti-Colorectal Cancer Compound Library Cancer Cell Differentiation Compound Library Anti-Ovarian Cancer Compound Library Anti-Aging Compound Library Reprogramming Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BML-284 853220-52-7 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin N-cadherin E-cadherin BML284 malformed phenotype Wnt inhibit AGS BML 284 Wnt agonist 1 TCF Inhibitor cardiac defect MNK45 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.