Powder: -20°C for 3 years | In solvent: -80°C for 1 year
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 32.00 | |
5 mg | In stock | $ 67.00 | |
10 mg | In stock | $ 117.00 | |
25 mg | In stock | $ 196.00 | |
50 mg | In stock | $ 289.00 | |
100 mg | In stock | $ 429.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 74.00 |
Description | iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity). |
Targets&IC50 | Wnt responsive STF16 luciferase:40.3 nM |
In vitro | iCRT14 can interfere with TCF binding to DNA in addition to its ability to influence TCF-β-cat interaction. iCRT14 (10, 25, 50 μM) effectively inhibits cell proliferation in BT-549 cells in a dose- and time-dependent manner but is still less potent than iCRT3. |
In vivo | CRT14 (50 mg/kg, i.p.) markedly decreases CycD1, proliferation of the tumors in HCT116 xenografts. |
Molecular Weight | 375.44 |
Formula | C21H17N3O2S |
CAS No. | 677331-12-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 28 mg/mL (74.6 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
iCRT 14 677331-12-3 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin iCRT14 iCRT-14 Wnt Inhibitor inhibit inhibitor