vegf-a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4288	HVEGF-IN-1		VEGFR
	hVEGF-IN-1 inhibits human VEGF-A translation and has antitumor activity.		VEGFR
TWA2417	Sodium taurocholate	Taurocholate Sodium	Others
	Sodium taurocholate (Taurocholate Sodium) hydrate is the main end product of cholesterol catabolism. During enterohepatic circulation, bile taurocholic acid is converted by the microorganisms to taurodeoxycholic acid and...		Others
T11153	EG00229		Others
	EG00229 is a neuropilin 1 (NRP1) receptor antagonist that selectively inhibits the binding of VEGF-A to the NRP1 b1 domain, achieving this inhibition with an IC50 value of 3 μM. It does not affect the binding of VEGF-A t...		Others
T4554	AG 1406		VEGFR
	AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.		VEGFR
TC0036	Compound Lup-20(29)-en-3-yl acetate		IL Receptor , VEGFR , Others , TNF , COX
	Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.		IL Receptor , VEGFR , Others , TNF , COX
T9928	Ranibizumab		VEGFR
	Ranibizumab is a humanized monoclonal antibody fragment designed to target and inhibit vascular endothelial growth factor (VEGF), including VEGF110, VEGF121, and VEGF165. Ranibizumab's ability to selectively target and n...		VEGFR
T19832	Acriflavine Hydrochloride	Acriflavine HCl	HIF
	Acriflavine Hydrochloride (Acriflavine HCl) is a HIF-1α inhibitor. It acts by targeting HIF-1α-mediated pathways and decreasing the level of PGK1, VEGF, and HIF-1α in vitro and in vivo.		HIF
T37424	CAY10781	CAY10781	Others
	CAY10781 is an inhibitor of the protein-protein interaction between neuropilin-1 (NRP-1) and VEGF-A.1It inhibits the interaction by 43% when used at a concentration of 12.5 μM. CAY10781 also inhibits VEGF-A-induced phosp...		Others
T9929	Ramucirumab		VEGFR
	Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors.		VEGFR
T8973	HS-1793		Others
	HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model		Others
T3567	SU 4942		Others
	SU-4942 is a modulator of tyrosine kinase signaling. SU-4942 has inhibitory effects on endothelial cell mitosis induced by VEGF and endothelial cell growth factor (ECGF).		Others
T61349	HIF-1α-IN-2		HIF
	HIF-1α-IN-2 is a novel and highly potent HIF-1α inhibitor with anticancer and antitumor activity that inhibits the expression of HIF-1α and VEGF in a dose-dependent manner and inhibits cell migration.		HIF
T3890	Verbenalin	Verbenalol β-D-glucopyranoside,Verbenaloside,Verbenalol glucoside,Cornin	Others
	Verbenalin (Verbenaloside) induces angiogenesis via a programmed PI3K/Akt/eNOS/VEGF signaling axis.		Others
T9904	Bevacizumab		VEGFR
	Bevacizumab, a humanized monoclonal antibody, specifically and with high affinity binds to all isoforms of VEGF-A.		VEGFR
T7836	ML228		HIF
	ML228 is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target VEGF.		HIF
T8496	MAZ51		Apoptosis , VEGFR
	MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.		Apoptosis , VEGFR
TP1886L1	NoxA1ds acetate(1435893-78-9 free base)		NADPH-oxidase
	NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human col...		NADPH-oxidase
T7203	Oglufanide	L-Glutamyl-L-tryptophan,H-Glu-Trp-OH	VEGFR , HCV Protease , Endogenous Metabolite
	Oglufanide (H-Glu-Trp-OH) is a naturally occurring thymic immunomodulator,and inhibits vascular endothelial growth factor (VEGF).		VEGFR , HCV Protease , Endogenous Metabolite
T3560	Desmethylanethol trithione	ADT-OH	VEGFR , Akt
	Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly...		VEGFR , Akt
T67836	AT-533		HSP , HSV
	AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, i...		HSP , HSV