Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 126.00 | |
25 mg | In stock | $ 255.00 | |
50 mg | In stock | $ 428.00 | |
100 mg | In stock | $ 639.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 53.00 |
Description | MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor. |
In vitro | MAZ51 is able to block the proliferation of VEGFR-3-expressing human endothelial cells and is less potently able to induce their apoptosis.?MAZ51 also inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines[1]. |
In vivo | In vivo, MAZ51 significantly inhibits the growth of rat mammary carcinomas.?These data establish MAZ51 as a compound with antitumor properties that inhibits tumor growth directly and also indirectly by interfering with tumor-host interactions[1]. |
Molecular Weight | 314.38 |
Formula | C21H18N2O |
CAS No. | 163655-37-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.33 mg/mL(10.59 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MAZ51 163655-37-6 Angiogenesis Apoptosis Tyrosine Kinase/Adaptors VEGFR EGFR growth phosphorylation Inhibitor inhibit PDGFRβ MAZ 51 tumor VEGF-D indolinone MAZ-51 IGF-1R VEGF-C Vascular endothelial growth factor receptor ligand-induced proliferation inhibitor