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Search Results for " transaminase "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T8765	IGOT1-01		Others
	iGOT1-01 is an effective inhibitor of glutamate oxaloacetate transaminase 1(GOT1) . iGOT1-01 has IC50s of 84.6 μM and 11.3 μM in GOT1/MDH1 assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 can be used in anti-cancer ...		Others
T8766	GOT1 inhibitor-1	GOT1 inhibitor 2c	Others
	GOT1 inhibitor-1 (GOT1 inhibitor 2c) is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM.		Others
T0128L	Vigabatrin Hydrochloride	γ-Vinyl-GABA hydrochloride	GABA Receptor
	Vigabatrin Hydrochloride (γ-Vinyl-GABA hydrochloride) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), which irreversibly inhibits the catabolism of GABA by GABA transaminase.		GABA Receptor
T40659L	γ-Acetylenic GABA hydrochloride	γ-Acetylenic GABA hydrochloride(57659-38-8 Free base)	Transaminase , GABA Receptor
	γ-Acetylenic GABA hydrochloride is a GABA transaminase inhibitor.		Transaminase , GABA Receptor
T67927	BAY-069		Reactive Oxygen Species
	BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at IC50:153 nM. BAY-069 is a novel (trifluoromethyl) pyrimidi...		Reactive Oxygen Species
T77795	L-DABA hydrobromide	L-2,4-Diaminobutyric acid hydrobromide	Others , Endogenous Metabolite
	L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) is a potent GABA transaminase inhibitor with antitumor and anticonvulsant activity for the study of neurological disorders.		Others , Endogenous Metabolite
T0128	Vigabatrin	Sabril,Vigabatrine	GABA Receptor , ABC
	Vigabatrin (Sabril), an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-aminobutyric acid.		GABA Receptor , ABC
T6474	Divalproex Sodium	Valproate semisodium,Epival	HDAC
	Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme...		HDAC
T7622L	Gabazine free base	Chebi:34968,SR95531,C13796,J331.170H,SR 95531
	Gabazine free base is a specific antagonist of the GABA receptor. It does not affect GABA-transaminase or glutamate-decarboxylase activities.
T24080	Gabaculine HCl	708-B,Gabaculine hydrochlorlide
	Gabaculine is an irreversible inhibitor of GABA transaminase (GABA-T; Ki: 2.9 μM). Gabaculine alters plastid development and differentially affects the abundance of plastid-encoded DPOR and nuclear-encoded GluTR.
T76364	Ac-Leu-Leu-Norleucinol
	Ac-Leu-Leu-Norleucinol (ALLN), a calpain inhibitor, is employed in the research of Acetaminophen-induced acute liver damage. It effectively reduces levels of glutamic-oxalacetic transaminase (ALT) and glutamic-pyruvic tr...
T40659	γ-Acetylenic GABA	4-Aminohex-5-ynoic acid,γ-Acetylenic GABA
	γ-Acetylenic GABA (4-Aminohex-5-ynoic acid) is a potent, irreversible inhibitor of GABA-transaminase. This compound effectively raises the concentration of γ-Aminobutyric acid (GABA) in the brain of rats.
T69068	Aspulvinone H
	Aspulvinone H is a natural inhibitor of glutamic oxaloacetate transaminase 1 (GOT1), suppressing glutamine metabolism, making PDAC cells sensitive to oxidative stress and inhibiting cell proliferation, exhibiting potent ...
T71305	Clofibric Acid-d4
	Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a ...
T62185	GABA-AT-IN-1
	GABA-AT-IN-1 (Compound 6) is an inhibitor of γ-aminobutyric acid transaminase (GABA-AT) that crosses the blood-brain barrier.
T76178	Aspartate aminotransferase
	Aspartate aminotransferase (AST) is a transaminase enzyme, is often used in biochemical studies. Aspartate aminotransferase catalyzes aspartate and alpha-ketoglutarate converts to oxaloacetate and glutamate. Aspartate am...
T37605	D-DOPA
	D-DOPA is an enantiomer of the dopamine precursor L-DOPA . It can be converted to L-DOPAviasequential oxidation and transamination, which are mediated by D-amino acid oxidase (DAAO) and DOPA transaminase, respectively, i...
T35799	MBX-8025 (sodium salt)
	MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increa...
T78059	Glucagon (Human)	Hyperglycemic-glycogenolytic factor,Glukagon	Others
	Glucagon significantly impacts protein and amino acid metabolism. It hinders the integration of amino acids into the proteins of the liver, muscle, and pancreas, augmenting nitrogen excretion and stimulating hepatic urea...		Others
T35816	ZLY032
	ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and...
T83735	Pap12-6 TFA
	Pap12-6, an antibacterial peptide originating from the first twelve N-terminal amino acids of papiliocin found in P. xuthus larvae, exhibits activity against a range of eight Gram-negative bacteria (e.g., E. coli, P. aer...

Compounds

Synonym: GOT1 inhibitor 2c

Target: Others

Vigabatrin Hydrochloride

T0128L

Synonym: γ-Vinyl-GABA hydrochloride

Target: GABA Receptor

γ-Acetylenic GABA hydrochloride

T40659L

Synonym: γ-Acetylenic GABA hydrochloride(57659-38-8 Free base)

Target: Transaminase, GABA Receptor

BAY-069

T67927

Synonym:

Target: Reactive Oxygen Species

L-DABA hydrobromide

T77795

Synonym: L-2,4-Diaminobutyric acid hydrobromide

Target: Others, Endogenous Metabolite

Vigabatrin

T0128

Synonym: Sabril,Vigabatrine

Target: GABA Receptor, ABC

Divalproex Sodium

T6474

Synonym: Valproate semisodium,Epival

Target: HDAC

Gabazine free base

T7622L

Synonym: Chebi:34968,SR95531,C13796,J331.170H,SR 95531

Target:

Gabaculine HCl

T24080

Synonym: 708-B,Gabaculine hydrochlorlide

Target:

Ac-Leu-Leu-Norleucinol

Synonym: 4-Aminohex-5-ynoic acid,γ-Acetylenic GABA

Aspartate aminotransferase

MBX-8025 (sodium salt)

Synonym: Hyperglycemic-glycogenolytic factor,Glukagon

Cat No.	Product Name	Synonyms	Targets
T7595	L-DABA	L-2,4-Diaminobutyric acid,L-DAB HBR	GABA Receptor , Endogenous Metabolite
	L-DABA (L-2,4-Diaminobutyric acid) is an inhibitor of GABA transaminase (IC50 > 500 μM).		GABA Receptor , Endogenous Metabolite
T6S1918	Schisantherin B	Gomisin-B,Wuweizi ester-B,Schizantherin-B	Beta Amyloid , Others
	1. Schisantherin B (Schizantherin-B) shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis.		Beta Amyloid , Others
T2S1814	P-Hydroxybenzaldehyde	4-Formylphenol,4-hydroxybenzaldehyde,p-Oxybenzaldehyde	Transaminase , GABA Receptor , Endogenous Metabolite
	1. p-Hydroxybenzaldehyde (p-Oxybenzaldehyde) shows an inhibitory effect on the GABA transaminase to contribute to an antiepileptic and anticonvulsive activity, and its inhibitory activity was higher than that of valproic...		Transaminase , GABA Receptor , Endogenous Metabolite
T3273	Bifendate	Bifendatatum	HBV , Reverse Transcriptase
	Bifendate (Bifendatatum) is commonly used to treat the transaminase elevation that caused by viral hepatitis and drug-induced liver injury.		HBV , Reverse Transcriptase
TN2185	Schisantherin C		Others
	Schisantherin A, B, C, and D show good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis.		Others
TN2181	Sarmentosin		Others
	Sarmentosin significantly lowers the SGPT level of patients suffering from chronic viral hepatitis, and shows a suppressive effect on cell-mediated immune responses in mice. It shows a good effect in lowering serum gluta...		Others
T82365	Fulvotomentoside B
	Fulvotomentoside B, a saponin derived from Lactobacillus flavus, displays hepatoprotective properties. It notably decreases serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) concentrations in mice sub...
T36179	Aspulvinone O
	Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulv...

Natural Products

L-DABA

T7595

Synonym: L-2,4-Diaminobutyric acid,L-DAB HBR

Target: GABA Receptor, Endogenous Metabolite

Schisantherin B

T6S1918

Synonym: Gomisin-B,Wuweizi ester-B,Schizantherin-B

Target: Beta Amyloid, Others

p-Hydroxybenzaldehyde

T2S1814

Synonym: 4-Formylphenol,4-hydroxybenzaldehyde,p-Oxybenzaldehyde

Target: Transaminase, GABA Receptor, Endogenous Metabolite

Bifendate

T3273

Synonym: Bifendatatum

Target: HBV, Reverse Transcriptase

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01100	GPT2 Protein, Rat, Recombinant (His)	Rat	Baculovirus-Insect Cells
	Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (Gpt), is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and pla...
TMPY-01099	GPT Protein, Rat, Recombinant (His)	Rat	Baculovirus-Insect Cells
	Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (GPT), is a pyridoxal enzyme that belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfa...
TMPH-00857	ABAT Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
TMPH-01598	CCBL2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the thre...
TMPY-03445	Aspartate Aminotransferase Protein, Human, Recombinant (His)	Human	E. coli
	GOT1 (Glutamic-Oxaloacetic Transaminase 1) is a Protein Coding gene. GOT1 belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent...
TMPH-01596	AADAT Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a vari...
TMPY-01189	GFPT1 Protein, Human, Recombinant	Human	E. coli
	Glutamine:fructose-6-phosphate amidotransferase 1 (GFAT), also known as GFPT1, is a member of the N-terminal nucleophile aminotransferases and the first rate-limiting enzyme for the entry of glucose into the hexosami...