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Gabaculine HCl

Catalog No. T24080 CAS 59556-17-1

Synonyms: 708-B, Gabaculine hydrochlorlide

Gabaculine is an irreversible inhibitor of GABA transaminase (GABA-T; Ki: 2.9 μM). Gabaculine alters plastid development and differentially affects the abundance of plastid-encoded DPOR and nuclear-encoded GluTR.

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Gabaculine HCl, CAS 59556-17-1

Pack Size	Availability	Price/USD
1 mg	35 days	$ 110.00
5 mg	35 days	$ 483.00
10 mg	35 days	$ 853.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	708-B, Gabaculine hydrochlorlide
Molecular Weight	175.61
Formula	C7H10ClNO2
CAS No.	59556-17-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bellucci M, De Marchis F, Ferradini N, Pompa A, Veronesi F, Rosellini D. A mutant Synechococcus gene encoding glutamate 1-semialdehyde aminotransferase confers gabaculine resistance when expressed in tobacco plastids. Plant Cell Rep. 2015 Dec;34(12):2127-36. doi: 10.1007/s00299-015-1856-z. Epub 2015 Aug 12. PubMed PMID: 26265112. 2. Demko V, Pavlovic A, Hudák J. Gabaculine alters plastid development and differentially affects abundance of plastid-encoded DPOR and nuclear-encoded GluTR and FLU-like proteins in spruce cotyledons. J Plant Physiol. 2010 Jun 15;167(9):693-700. doi: 10.1016/j.jplph.2009.12.008. Epub 2010 Feb 2. PubMed PMID: 20129699. 3. Orriss GL, Patel TR, Sorensen J, Stetefeld J. Absence of a catalytic water confers resistance to the neurotoxin gabaculine. FASEB J. 2010 Feb;24(2):404-14. doi: 10.1096/fj.09-138297. Epub 2009 Sep 28. PubMed PMID: 19786580. 4. Irifune M, Katayama S, Takarada T, Shimizu Y, Endo C, Takata T, Morita K, Dohi T, Sato T, Kawahara M. MK-801 enhances gabaculine-induced loss of the righting reflex in mice, but not immobility. Can J Anaesth. 2007 Dec;54(12):998-1005. PubMed PMID: 18056209.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Gabaculine HCl 59556-17-1 708-B Gabaculine hydrochlorlide inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.