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iGOT1-01

Catalog No. T8765 CAS 882256-55-5

iGOT1-01 is an effective inhibitor of glutamate oxaloacetate transaminase 1(GOT1) . iGOT1-01 has IC50s of 84.6 μM and 11.3 μM in GOT1/MDH1 assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 can be used in anti-cancer studies.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

iGOT1-01, CAS 882256-55-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 115.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 463.00
25 mg	In stock	$ 748.00
50 mg	In stock	$ 987.00
100 mg	In stock	$ 1,380.00
500 mg	In stock	$ 2,770.00
1 mL * 10 mM (in DMSO)	In stock	$ 318.00

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Purity: 99.83%

Purity: 98.16%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	iGOT1-01 is an effective inhibitor of glutamate oxaloacetate transaminase 1(GOT1) . iGOT1-01 has IC50s of 84.6 μM and 11.3 μM in GOT1/MDH1 assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 can be used in anti-cancer studies.
Targets&IC50	GOT1/MDH1:84.6 μM, GOT1/GLOX/HRP:11.3 μM
In vitro	iGOT1-01 (3.125-200 μM; for 3 h) reveals little to no toxicity using two readouts of cell viability in PaTu8902 pancreatic and DLD1 colon cancer cells. No inhibitory activity is observed for iGOT1-01 against MDH1 alone at 100 μM[1].
In vivo	In female CD1 mice, iGOT1-01 (20 mg/kg; oral) has reasonable bioavailability and exposure properties (t1/2=0.7 hours, Cmax=4133 ng/mL, AUC(0-24 hours)=11734 hour ng/mL)[2].

Molecular Weight	320.39
Formula	C19H20N4O
CAS No.	882256-55-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 98 mg/mL (305.88 mM), Sonication is recommended.

References and Literature

1. Melissa C Holt, et al. Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry. 2018 Nov 27;57(47):6604-6614. 2. Justin Anglin, et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

iGOT1-01 882256-55-5 Others GLOX aspartate Inhibitor anti-cancer transaminase inhibit iGOT1 01 GOT1 HRP aminotransferase glutamate iGOT101 MDH oxaloacetate inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.