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Search Results for " trx "

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T39915	Trx-red	Trx-red,NBL-SS perchlorate
	Trx-red (NBL-SS perchlorate) is a red-emitting fluorescent probe derived from the nile blue fluorophore. It is specifically designed for imaging thioredoxin (Trx) in live cells and in vivo, with excitation and emission w...
T39586	Cantrixil	TRX-E-002-1
	Cantrixil (TRX-E-002-1) is a second-generation super-benzopyran (SBP) compound, derived from TRX-E-002. It elicits an increase in phosphorylated c-Jun levels, leading to caspase-mediated apoptosis in ovarian cancer cells...
T3389	Antitumor agent-21	TRX818	Others
	Antitumor agent-21 (TRX818) is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities.		Others
T30849	CGP-59326	UNII-YP9UZR062O,CGP59326,CGP 59326,TRX-13
	CGP-59326 is an epidermal growth factor receptor (EGFR) antagonist, which is used in anti-cancer research.
T13230	TXNIP-IN-1		Others
	TXNIP-IN-1 is an inhibitor of the TXNIP-TRX complex and used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease.		Others
T68257	Hydromethylthionine HBr
	Hydromethylthionine, also known as LMTM and Leucomethylene Blue, is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Hydromethylthionine showed pharmacologi...
T7003	Leucomethylene blue mesylate	TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate	Beta Amyloid , Microtubule Associated
	Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.		Beta Amyloid , Microtubule Associated
T7714	Temocapil		Tyrosinase
	Temocapril is an inhibitor of tyrosine kinase.		Tyrosinase
T6698	Temocapril hydrochloride	CS-622 HCl,Acecol,Temocapril HCl,CS-622	RAAS
	Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension.		RAAS
T29017	TrxR1-IN-B19	TrxR1INB19,Go Y015,TrxR1 IN B19,Go-Y015	Others
	TrxR1-IN-B19 (TrxR1 IN B19), a TrxR1 inhibitor, selectively kills gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation.		Others
T14835	BTRX-335140	CYM-53093	Opioid Receptor
	BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively. BTRX-335140...		Opioid Receptor
T62021	TrxR-IN-2
	TrxR-IN-2 is a potential thioredoxin reductase (TrxR) inhibitor. TrxR-IN-2 has research value in the chemotherapy of drug-resistant hepatocellular carcinoma.
T78781	TrxR1-IN-1
	Compound 5j, also known as TrxR1-IN-1, is a TrxR1 inhibitor with an IC50 of 8.8 μM. It exhibits anticancer activity, demonstrating IC50 values of 1.5 μM in MCF-7, 1.7 μM in HeLa, 2.4 μM in BGC-823, 2.8 μM in SW-480, and ...
T60453	TrxR-IN-3
	TrxR-IN-3 (Compound 2c) is a effective TrxR inhibitor. TrxR-IN-3 shows strong antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and l...
T61647	TrxR-IN-5
	TrxR-IN-5 (compound 4f) is an efficacious inhibitor of TrxR (thioredoxin reductase) with an IC50 of 0.16 μM. By elevating the levels of reactive oxygen species (ROS), TrxR-IN-5 fosters robust antiproliferative impacts. A...
T73254	TrxR-IN-4
	Compound 1b (TrxR-IN-4) is a potent TrxR inhibitor that activates endoplasmic reticulum stress (ERS) to induce apoptosis in HepG2 cells and mitigates CCl4-induced liver damage in vivo through TrxR expression down-regulat...
T29018	TrxR inhibitor D9	D9,TrxR-IN-D9
	TrxR-IN-D9 is a novel inhibitor of thioredoxin reductase (TrxR).
T73992	IONIS-MAPTRx
	IONIS-MAPTRx (BIIB080) is the first Tau-lowering antisense oligonucleotide (ASO). IONIS-MAPTRx has the potential for the research of Alzheimer Disease [1] . ( MCE IONIS-MAPTRx for murine use [3] : Tau ASO-12 sequence – 5...
T2283	PX-12	IV-2,PX12	Thioredoxin
	PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor gr...		Thioredoxin
TP1604L	Thioredoxin reductase peptide acetate	Thioredoxin reductase peptide acetate(950890-23-0 free base)	Others
	Thioredoxin reductase peptide acetate corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research.Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redox-active...		Others
T23166	PMX 464		Others
	inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system		Others
T28906	T6603185	T-6603185,T 6603185
	T6603185 is a novel inhibitor of peroxiredoxin (Prx) and thioredoxin (Trx) systems.
T83871	Ferroptocide
	Ferroptocide, a thioredoxin (Trx) inhibitor and pleuromutilin derivative, exhibits inhibitory activity against Trx in ES-2 ovarian cancer cells at a concentration of 20 µM and demonstrates cytotoxicity towards these cell...
T15062	DBCO-NHCO-PEG4-amine		Others
	DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1].		Others
TP1604	Thioredoxin reductase peptide
	Thioredoxin reductase peptide corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research.Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redox-active disulfi...

Compounds

Trx-red

T39915

Synonym: Trx-red,NBL-SS perchlorate

Target:

Cantrixil

T39586

Synonym: TRX-E-002-1

Synonym: UNII-YP9UZR062O,CGP59326,CGP 59326,TRX-13

Hydromethylthionine HBr

T68257

Synonym:

Target:

Leucomethylene blue mesylate

T7003

Synonym: TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate

Target: Beta Amyloid, Microtubule Associated

Temocapril hydrochloride

T6698

Synonym: CS-622 HCl,Acecol,Temocapril HCl,CS-622

Target: RAAS

TrxR1-IN-B19

T29017

Synonym: TrxR1INB19,Go Y015,TrxR1 IN B19,Go-Y015

Target: Opioid Receptor

Synonym: D9,TrxR-IN-D9

Thioredoxin reductase peptide acetate

TP1604L

Synonym: Thioredoxin reductase peptide acetate(950890-23-0 free base)

Synonym: T-6603185,T 6603185

Thioredoxin reductase peptide

TP1604

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00382	Thioredoxin/TRX Protein, Mouse, Recombinant	Mouse	E. coli
	Thioredoxin/TRX Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.7 kDa and the accession number is P10639.
TMPY-02250	Thioredoxin/TRX Protein, Human, Recombinant	Human	E. coli
	Thioredoxin/TRX Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.7 kDa and the accession number is P10599.
TMPJ-01145	ABCB5 Protein, Human, Recombinant (Trx)	Human	E. coli
	ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progen...
TMPH-02781	Merlin Protein, Mouse, Recombinant (His & Trx)	Mouse	E. coli
	Merlin Protein, Mouse, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-Trx tag. The predicted molecular weight is 55.9 kDa and the accession number is P46662.
TMPJ-00361	Endoglin Protein, Human, Recombinant (Trx & His)	Human	E. coli
	Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, a...
TMPJ-00898	CD72 Protein, Human, Recombinant (Trx & His)	Human	E. coli
	B-Cell Differentiation Antigen CD72 (CD72) is a single-pass type II membrane protein. CD72 exists as a disulfide-linked homodimer and contains one C-type lectin domain. CD72 is expressed on B lineage cells, NK cells, mon...
TMPY-02084	Thioredoxin 2/TRX2 Protein, Human, Recombinant (His)	Human	E. coli
	Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanot...
TMPH-01026	CAMK2N1 Protein, Human, Recombinant (His & Trx)	Human	E. coli
	Potent and specific inhibitor of CaM-kinase II (CAMK2). CAMK2N1 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-Trx tag. The predicted molecular weight is 25.6 kDa and the a...
TMPJ-00971	PPIC Protein, Human, Recombinant (Trx & His)	Human	E. coli
	Cyclophilin C is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restra...
TMPY-02194	SOCS3 Protein, Human, Recombinant (His & Trx)	Human	E. coli
	Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, plac...
TMPH-01560	IL-26 Protein, Human, Recombinant (His & Trx)	Human	E. coli
	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expre...
TMPJ-00826	TXN Protein, Human, Recombinant (His)	Human	E. coli
	Thioredoxin (TXN) is a member of the Thioredoxin family. Thioredoxin exists as a disulfide-linked homodimer and contains one Thioredoxin domain. Thioredoxin is up-regulated by ionizing radiation. Thioredoxin participates...
TMPY-05297	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx)	Human	E. coli
	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with His and Trx tag. The predicted molecular weight is 51.3 kDa and the accession number is P02649.
TMPY-05528	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated	Human	E. coli
	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated is expressed in E. coli expression system with His and Trx tag. The predicted molecular weight is 51.3 kDa and the accession number is P02649.
TMPY-02430	BCL6 Protein, Human, Recombinant (aa 1-150, His & Trx)	Human	E. coli
	The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexe...
TMPY-05271	CD20 Protein, Human, Recombinant (TrxA), Biotinylated	Human	E. coli
	CD20 Protein, Human, Recombinant (TrxA), Biotinylated is expressed in E. coli expression system with TrxA tag. The predicted molecular weight is 23.9 kDa and the accession number is A0A024R507.
TMPY-04615	CD20 Protein, Human, Recombinant (TrxA)	Human	E. coli
	CD20 Protein, Human, Recombinant (TrxA) is expressed in E. coli expression system with TrxA tag. The predicted molecular weight is 23.9 kDa and the accession number is A0A024R507.
TMPY-02271	TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His)	Human	E. coli
	Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidat...
TMPY-02572	TXNDC17 Protein, Human, Recombinant	Human	E. coli
	Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein fa...