keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 50.00 | |
10 mg | In stock | $ 68.00 | |
25 mg | In stock | $ 123.00 | |
50 mg | In stock | $ 203.00 | |
100 mg | In stock | $ 349.00 | |
200 mg | In stock | $ 526.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. |
Targets&IC50 | Tau:0.12 μM (Ki) |
In vitro | TRx 0237 (LMTX?) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. It is a purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria as well as for methemoglobinemia and other conditions[2]. An in vitro study showed the ability of TRx 0237 in disrupting PHFs(paired helical filaments) isolated from Alzheimer's Disease brain tissues at the concentration at 0.16 μM[1]. |
In vivo | TRx 0237 dose-dependently rescues the learning impairment and restores behavioral flexibility in a spatial problem-solving water-maze task in L1 (minimum effective dose: 9 mg MT/kg for TRx0237) and correctes motor learning in L66 (effective doses: 4 mg MT/kg). It reduces the number of tau-reactive neurons, particularly in the hippocampus and entorhinal cortex in L1 and in a more widespread manner in L66[1]. |
Synonyms | TRx0237 mesylate, TRx0237 (LMTX) mesylate, Methylene blue leuco base mesylate salt, Leucomethylene Blue Dimesylate |
Molecular Weight | 477.62 |
Formula | C16H19N3S·2CH4O3S |
CAS No. | 1236208-20-0 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: 87 mg/mL (182.2 mM)
DMSO: 88 mg/mL (184.2 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Leucomethylene blue mesylate 1236208-20-0 Cytoskeletal Signaling Neuroscience Microtubule Associated Beta Amyloid TRx-0237 Methylene blue leuco base Aβ25-35 aggregation Tau Methylene blue leuco base Mesylate Inhibitor TRx0237 mesylate Leucomethylene blue Mesylate inhibit TRx0237 (LMTX) Mesylate β-amyloid peptide Amyloid-β Disease Leucomethylene Blue Leucomethylene blue TRx0237 TRx0237 (LMTX) mesylate TRx0237 Mesylate TRx 0237 Methylene blue leuco base mesylate salt Alzheimer's Leucomethylene Blue Dimesylate Abeta inhibitor