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Temocapril hydrochloride

Catalog No. T6698 CAS 110221-44-8

Synonyms: CS-622 HCl, Acecol, Temocapril HCl, CS-622

Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension.

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Temocapril hydrochloride Chemical Structure

Temocapril hydrochloride, CAS 110221-44-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 31.00
10 mg	In stock	$ 48.00
25 mg	In stock	$ 95.00
50 mg	In stock	$ 148.00
100 mg	In stock	$ 232.00
200 mg	In stock	$ 343.00
1 mL * 10 mM (in DMSO)	In stock	$ 35.00

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Purity: 99.35%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension.

Kinase Assay

C2C12 cells are seeded into 96-well plates at 2,000 cells per well in DMEM supplemented with 2% FBS. The wells are treated in quadruplicate with BMP ligands and LDN-193189 or vehicle. The cells are collected after 6 d in culture in 50 μL Tris-buffered saline and 1% Triton X-100. The lysates are added to p-nitro-phenylphosphate reagent in 96-well plates for 1 h and then evaluated alkaline phosphatase activity (absorbance at 405 nm). Cell viability are measured and quantity by Cell Titer Aqueous One (absorbance at 490 nm), using replicate wells treated identically to those used for alkaline phosphatase measurements[1].

Synonyms	CS-622 HCl, Acecol, Temocapril HCl, CS-622
Molecular Weight	513.07
Formula	C23H28N2O5S2·HCl
CAS No.	110221-44-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 95 mg/mL (185.2 mM)

DMSO: 95 mg/mL (185.2 mM)

References and Literature

1. Suzuki H, Kawaratani T, Shioya H, Uji Y,Saruta T.Biopharm Drug Dispos. 1993 Jan;14(1):41-50.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Bioactive Compounds Library Max Anti-Hypertension Compound Library NO PAINS Compound Library Endocrinology-Hormone Compound Library Anti-Metabolism Disease Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library

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Related compounds with same targets

Plantainoside D DX600 TFA H-Val-Pro-Pro-OH Valsartan Methyl Ester Moveltipril C-Type Natriuretic Peptide (CNP) (1-22), human Omapatrilat Olmesartan

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Temocapril hydrochloride 110221-44-8 Endocrinology/Hormones RAAS CS-622 HCl hypertension CES1 acute myocardial infarction Temocapril Angiotensin-converting Enzyme (ACE) heart failure insulin resistance Acecol Inhibitor neonatal rat cardiomyocytes enzyme Cu/ZnSOD redox proteins TRX human carboxylesterase Temocapril HCl Angiotensin (I) CS 622 Temocaprilat inhibit CS-622 angiotensin-converting CS622 renal diseases Temocapril Hydrochloride N-acetyltetradecapeptide renin substrate Mn-SOD inhibitor

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