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Search Results for " thp1 "

13

Compounds

Cat No. Product Name Synonyms Targets
T8655 SR-717 STING
SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.
T13774 ML390 Others , Dehydrogenase
ML390 exerts its potent differentiation effect on multiple leukemia models.
T11344 G150 DNA , cGAS
G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS).
T9777 THP104c Mitochondrial Metabolism
THP104c is an inhibitor of mitochondrial fission.
TQ0198 Phorbol 12-myristate 13-acetate PMA NF-κB , S1P Receptor , PKC
Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13-acetate induces THP1 cell differentiation.
T8477 IQ-3 JNK
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α an...
T29097 VAS 3947 VA-S3947,VA S3947,VAS3947 Apoptosis , NADPH-oxidase
VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX act...
T74328 STING agonist-8 dihydrochloride
STING Agonist-8 Dihydrochloride (Compound 5-AB) is a highly effective STING agonist, exhibiting an EC50 value of 27 nM in THP1-Dual KI-hSTING-R232 cells.
T26775 Bepafant WEB-2170,WEB2170,STY 2108,STY-2108,WEB 2170
Bepafant is a platelet activating factor (PAF) antagonist. Bepafant may produce significant anti-inflammatory effects. Bepafant triggered apoptosis in NB4, KG1, and NB4-MR4 cells where PTEN was expressed, but not in THP1...
T39926 SR-717 free acid
SR-717 free acid is a stable cGAMP mimetic and a non-nucleotide STING agonist. It exhibits antitumor activity with EC50 values of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively...
T81667 NLRP3 agonist 2 NOD-like Receptor (NLR)
NLRP3 agonist 2 (compound 22) is an orally active agent that activates Caspase-1 in THP1 cells [1].
T78854 WK499
BCL6-IN-10 (Compound WK499) is an inhibitor of BCL6, disrupting its interaction with the SMRT protein and promoting apoptosis, cell cycle arrest, and DNA damage. It effectively hampers the proliferation of various AML ce...
T36798L SW2_110A acetate Histone Methyltransferase
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate has a high affinity for CBX8N, inhibits the association bet...
TargetMol