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G150

Catalog No. T11344   CAS 2369751-30-2

G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS).

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G150 Chemical Structure
G150, CAS 2369751-30-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 135.00
5 mg In stock $ 289.00
10 mg In stock $ 455.00
25 mg In stock $ 753.00
50 mg In stock $ 1,060.00
100 mg In stock $ 1,430.00
1 mL * 10 mM (in DMSO) In stock $ 317.00
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Purity: 97.39%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS).
Targets&IC50 cGAS (human):10.2 nM
In vitro G150 showed dose-dependent inhibitory activity in THP1 cells with cellular IC50 of 1.96 μM[1].
Molecular Weight 391.25
Formula C18H16Cl2N4O2
CAS No. 2369751-30-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (306.71 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Lama L, et al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21;10(1):2261.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Inhibitor Library NO PAINS Compound Library Bioactive Compound Library DNA Damage & Repair Compound Library Bioactive Compounds Library Max

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Keywords

G150 2369751-30-2 DNA Damage/DNA Repair Immunology/Inflammation DNA cGAS human myeloid cell macrophage dsDNA THP1 Cyclic GMP-AMP Synthase G 150 Inhibitor G-150 anti-inflammatory high-throughput screening inhibit inhibitor

 

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