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G150

Catalog No. T11344 CAS 2369751-30-2

G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS).

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G150, CAS 2369751-30-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS).
Targets&IC50	h-cGAS:10.2 nM
In vitro	G150 showed dose-dependent inhibitory activity in THP1 cells with cellular IC50 of 1.96?μM[1].

Molecular Weight	391.25
Formula	C18H16Cl2N4O2
CAS No.	2369751-30-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 120 mg/mL (306.71 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lama L, et al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21;10(1):2261.

Related Products

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G140 RU.521 PF-06928215 IRAK4-IN-4 G150

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Keywords

G150 2369751-30-2 DNA损伤和修复免疫与炎症 cGAS DNA human myeloid cell macrophage G 150 dsDNA THP1 Cyclic GMP-AMP Synthase Inhibitor G-150 anti-inflammatory high-throughput screening inhibit inhibitor

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