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SR-717

Name: SR-717
Brand: TargetMol
SKU: T8655
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8655Cas No. 2375421-09-1

SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.

SR-717

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Purity: 99.88%

Catalog No. T8655Cas No. 2375421-09-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
2 mg	$45	In Stock	In Stock
5 mg	$73	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$259	In Stock	In Stock
50 mg	$417	In Stock	In Stock
100 mg	$662	In Stock	In Stock
200 mg	$926	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$135	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.
Targets&IC50	STING (B16 cells):7.8 µM, ISG-THP1 (WT) cells:2.1 μM (EC50), ISG-THP1 cGAS KO (cGAS KO) cells:2.2 μM (EC50)
In vitro	METHODS: Macrophage THP1 were treated with SR-717 (3.6 µM) for 10 min-6 h. The expression levels of target proteins were detected using Western Blot. RESULTS: SR-717 activates p-STING, and its downstream p-TBK1, p-IRF3, p-p65, p-STAT1 and p-STAT3. [1] METHODS: Primary human peripheral blood mononuclear cell PBMCs were treated with SR-717 (10 µM) for 2-6 h. Gene expression levels were detected using RT-qPCR. RESULTS: SR-717 stimulated the activation of IFNB1, CXCL10 and IL6. [1]
In vivo	METHODS: To test the antitumor activity in vivo, SR-717 (30 mg/kg) was injected intraperitoneally into WT or Stinggt/gt C57BL/6 mice bearing mouse cutaneous melanoma tumor B16.F10 once daily for seven days. RESULTS: SR-717 inhibited tumor growth as well as prolonged the survival time of mice with rhabdomyosarcoma. The antitumor effect of SR-717 showed an enforced dependence on STING expression, and a lack of activity was observed in Stinggt/gt mice. [1] METHODS: To assay antitumor activity in vivo, SR-717 (10 mg/kg) was administered intravenously three times every two days to C57BL/6 mice harboring mouse cutaneous melanin tumor B16.F10. RESULTS: SR-717 has anti-tumor activity in vivo and prolongs survival. [2]

Chemical Properties

Molecular Weight	351.19
Formula	C₁₅H₈F₂LiN₅O₃
Cas No.	2375421-09-1
Smiles	[Li+].[O-]C(=O)c1cc(F)c(F)cc1NC(=O)c1ccc(nn1)-n1ccnc1
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (56.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (7.12 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8475 mL	14.2373 mL	28.4746 mL	142.3731 mL
5 mM	0.5695 mL	2.8475 mL	5.6949 mL	28.4746 mL
10 mM	0.2847 mL	1.4237 mL	2.8475 mL	14.2373 mL
20 mM	0.1424 mL	0.7119 mL	1.4237 mL	7.1187 mL
50 mM	0.0569 mL	0.2847 mL	0.5695 mL	2.8475 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc