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SR-717

Catalog No. T8655 CAS 2375421-09-1

SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.

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SR-717, CAS 2375421-09-1

Pack Size	Availability	Price/USD
2 mg	In stock	$ 75.00
5 mg	In stock	$ 124.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 374.00
50 mg	In stock	$ 541.00
100 mg	In stock	$ 719.00
1 mL * 10 mM (in DMSO)	In stock	$ 136.00

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Purity: 99.79%

Purity: 99.04%

Purity: 98.64%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.
In vitro	METHODS: Macrophage THP1 were treated with SR-717 (3.6 µM) for 10 min-6 h. The expression levels of target proteins were detected using Western Blot. RESULTS: SR-717 activates p-STING, and its downstream p-TBK1, p-IRF3, p-p65, p-STAT1 and p-STAT3. [1] METHODS: Primary human peripheral blood mononuclear cell PBMCs were treated with SR-717 (10 µM) for 2-6 h. Gene expression levels were detected using RT-qPCR. RESULTS: SR-717 stimulated the activation of IFNB1, CXCL10 and IL6. [1]
In vivo	METHODS: To test the antitumor activity in vivo, SR-717 (30 mg/kg) was injected intraperitoneally into WT or Stinggt/gt C57BL/6 mice bearing mouse cutaneous melanoma tumor B16.F10 once daily for seven days. RESULTS: SR-717 inhibited tumor growth as well as prolonged the survival time of mice with rhabdomyosarcoma. The antitumor effect of SR-717 showed an enforced dependence on STING expression, and a lack of activity was observed in Stinggt/gt mice. [1] METHODS: To assay antitumor activity in vivo, SR-717 (10 mg/kg) was administered intravenously three times every two days to C57BL/6 mice harboring mouse cutaneous melanin tumor B16.F10. RESULTS: SR-717 has anti-tumor activity in vivo and prolongs survival. [2]

Molecular Weight	351.19
Formula	C15H8F2LiN5O3
CAS No.	2375421-09-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (71.19 mM), Sonication is recommended.

References and Literature

1. Chin EN, et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science. 2020 Aug 21;369(6506):993-999. 2. Li L, et al. Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy. Nat Commun. 2023 Aug 22;14(1):5111.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Immunology/Inflammation Compound Library NO PAINS Compound Library Immuno-Oncology Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library

Related Products

Related compounds with same targets

BI 7446 LB244 SN-008 SAP-04 STING agonist-30 STING agonist-1 SN-011 C-178

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Keywords

SR-717 2375421-09-1 Immunology/Inflammation STING immunity MPYS MITA inhibit ISG-THP1 Inhibitor mimetic TMEM173 cGAMP SR717 THP1 antitumor SR 717 ERIS PD-L1 Stimulator of Interferon Genes inhibitor

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