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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T63429 | SMO-IN-2 | Hedgehog/Smoothened | |
SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of c... | |||
T63387 | SMO-IN-3 | ||
SMO-IN-3 is a potent inhibitor of smoothened (SMO) that acts on the hedgehog (Hh) signaling pathway (IC50: 34.09 nM). SMO-IN-3 inhibits the proliferation of Daoy, a human medulloblastoma cell line, and exhibits anticance... | |||
T61897 | SMO-IN-1 | ||
SMO-IN-1 (Compound 15) is an oral effective Smoothened (SMO) inhibitor. The EC50 value of sonic Hh protein (shh) is 89 nM. | |||
T3460 | HhAntag | Hedgehog/Smoothened , Smo | |
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity. | |||
T23027 | MRT-10 | Hedgehog/Smoothened | |
MRT-10 is a Smoothened (Smo) receptor antagonist. | |||
T14188 | ALLO-2 | Hedgehog/Smoothened , Smo | |
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. | |||
T12109 | MRT-83 | Smo | |
MRT-83 is a potent Smo antagonist. | |||
T9531 | MRT-14 | Smo | |
MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies. | |||
T6891 | MK-4101 | Apoptosis , Hedgehog/Smoothened , Smo | |
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in tumor cells. | |||
T2450 | SANT-1 | SANT 1 | Hedgehog/Smoothened , Smo |
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM). | |||
T2666 | Taladegib | LY2940680 | Hedgehog/Smoothened , Smo |
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. | |||
T2825 | Cyclopamine | 11-Deoxojervine | Hedgehog/Smoothened , Endogenous Metabolite , Smo |
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids. | |||
T6514 | Glasdegib | PF-04449913 | Hedgehog/Smoothened , Smo |
Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2. | |||
T24159 | IHR-1 | IHR 1 | Smo |
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. | |||
T1810 | Purmorphamine | Shh Signaling Antagonist VI | Hedgehog/Smoothened , Smo , Autophagy |
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation. | |||
T1779 | SAG | Smoothened Agonist (SAG) HCl,Smoothened Agonist | Hedgehog/Smoothened , Smo |
SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway. | |||
T11838 | LEQ506 | NVP-LEQ506 | Smo |
LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively. | |||
T2299 | BMS-833923 | XL-139 | Apoptosis , Hedgehog/Smoothened , Smo |
BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM). | |||
T22814 | GSA-10 | Hedgehog/Smoothened | |
Smoothened (Smo) receptor agonist | |||
T5465 | PF-5274857 | PF-5274857 freebase | Smo |
PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor t... |