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LEQ506

Catalog No. T11838 CAS 1204975-42-7

Synonyms: NVP-LEQ506

LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

LEQ506, CAS 1204975-42-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 163.00
5 mg	In stock	$ 413.00
10 mg	In stock	$ 618.00
25 mg	In stock	$ 985.00
50 mg	In stock	$ 1,330.00
100 mg	In stock	$ 1,790.00
500 mg	In stock	$ 3,590.00
1 mL * 10 mM (in DMSO)	In stock	$ 455.00

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Purity: 98.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.
Targets&IC50	Smo (mouse):4 nM , Smo (human):2 nM
In vitro	LEQ506 consistently decreases Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and 60 to 70% for Ptch1[1]. LEQ506 inhibits Hedgehog signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC50 ~6-fold lower than that of Compound 2[2].

Synonyms	NVP-LEQ506
Molecular Weight	432.56
Formula	C25H32N6O
CAS No.	1204975-42-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (231.18 mM)

References and Literature

1. Lauressergues E, et al. Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model. Pharmacol Res Perspect. 2016 Mar 4;4(2):e00214. 2. Peukert S, et al. Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened. ChemMedChem. 2013 Aug;8(8):1261-5.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Drug Library Orally Active Compound Library Bioactive Compound Library Anti-Cancer Compound Library Clinical Compound Library ReFRAME Related Library

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Related compounds with same targets

20(S)-Hydroxycholesterol IHR-1 SANT-1 Taladegib Jervine MRT-83 SAG JNJ-1289

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LEQ506 1204975-42-7 Stem Cells Smo Inhibitor NVP-LEQ-506 LEQ 506 Smoothened inhibit NVP-LEQ 506 LEQ-506 NVP-LEQ506 inhibitor

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