Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
2 mg | In stock | $ 59.00 | |
5 mg | In stock | $ 93.00 | |
10 mg | In stock | $ 145.00 | |
25 mg | In stock | $ 252.00 | |
50 mg | In stock | $ 401.00 | |
100 mg | In stock | $ 597.00 | |
500 mg | In stock | $ 1,290.00 |
Description | Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. |
In vitro | LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers had previously observed in patient with cancer who developed resistance to vismodegib. [1] |
In vivo | LY2940680 has excellent pharmacokinetic properties in rodent and non-rodent species. LY2940680 administrated orally treats Ptch+/- p53-/- transgenic mice which spontaneously develop medulloblastoma, produces remarkable efficacy and significantly improves their survival. LY2940680 reveals rapid kinetics of anti-tumor activity through magnetic resonance imaging of these mice, and LY2940680 induces Caspase-3 activity and reduces proliferation by immunohistochemistry analysis of medulloblastoma tumors. LY2940680 inhibits Hh regulated gene expression in the subcutaneous xenograft tumor stroma and produces significant anti-tumor activity. [2] |
Synonyms | LY2940680 |
Molecular Weight | 512.5 |
Formula | C26H24F4N6O |
CAS No. | 1258861-20-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.64 mg/mL (11 mM)
You can also refer to dose conversion for different animals. More
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Taladegib 1258861-20-9 GPCR/G Protein Stem Cells Smo Hedgehog/Smoothened inhibit LY 2940680 LY-2940680 LY2940680 Inhibitor Smoothened inhibitor