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Taladegib

Catalog No. T2666 CAS 1258861-20-9

Synonyms: LY2940680

Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity.

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Taladegib, CAS 1258861-20-9

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity.
In vitro	LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers had previously observed in patient with cancer who developed resistance to vismodegib. [1]
In vivo	LY2940680 has excellent pharmacokinetic properties in rodent and non-rodent species. LY2940680 administrated orally treats Ptch+/- p53-/- transgenic mice which spontaneously develop medulloblastoma, produces remarkable efficacy and significantly improves their survival. LY2940680 reveals rapid kinetics of anti-tumor activity through magnetic resonance imaging of these mice, and LY2940680 induces Caspase-3 activity and reduces proliferation by immunohistochemistry analysis of medulloblastoma tumors. LY2940680 inhibits Hh regulated gene expression in the subcutaneous xenograft tumor stroma and produces significant anti-tumor activity. [2]

Synonyms	LY2940680
Molecular Weight	512.513
Formula	C26H24F4N6O
CAS No.	1258861-20-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Redmond EM et al. Expert Opin Investig Drugs, 2011, 20(12),1649-1664. 2. Mark H. Bender, Cancer Research, 2011, Volume 71, Issue 8, Supplement1

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Preclinical Compound Library Anti-Lung Cancer Compound Library GPCR Compound Library Anti-Obesity Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Wnt/Hedgehog/Notch Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library

Related Products

Related compounds with same targets

Glasdegib HhAntag Triparanol SMANT hydrochloride MRT-10 GSA-10 HPI 1 TAK-441

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Taladegib 1258861-20-9 G蛋白偶联受体干细胞 Hedgehog/Smoothened Smo inhibit LY-2940680 LY2940680 Inhibitor LY 2940680 Smoothened inhibitor

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