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Taladegib

Taladegib
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Purity:100%
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Taladegib

Catalog No. T2666Cas No. 1258861-20-9
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity.
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Pack SizePriceAvailabilityQuantity
1 mg$41In Stock
2 mg$59In Stock
5 mg$93In Stock
10 mg$145In Stock
25 mg$252In Stock
50 mg$401In Stock
100 mg$597In Stock
500 mg$1,290In Stock
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Product Introduction

Bioactivity
Description
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity.
In vitro
LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers had previously observed in patient with cancer who developed resistance to vismodegib. [1]
In vivo
LY2940680 has excellent pharmacokinetic properties in rodent and non-rodent species. LY2940680 administrated orally treats Ptch+/- p53-/- transgenic mice which spontaneously develop medulloblastoma, produces remarkable efficacy and significantly improves their survival. LY2940680 reveals rapid kinetics of anti-tumor activity through magnetic resonance imaging of these mice, and LY2940680 induces Caspase-3 activity and reduces proliferation by immunohistochemistry analysis of medulloblastoma tumors. LY2940680 inhibits Hh regulated gene expression in the subcutaneous xenograft tumor stroma and produces significant anti-tumor activity. [2]
AliasLY2940680
Chemical Properties
Molecular Weight512.5
FormulaC26H24F4N6O
Cas No.1258861-20-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 5.64 mg/mL (11 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9512 mL9.7561 mL19.5122 mL97.5610 mL
5 mM0.3902 mL1.9512 mL3.9024 mL19.5122 mL
10 mM0.1951 mL0.9756 mL1.9512 mL9.7561 mL

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