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BMS-833923

Catalog No. T2299 CAS 1059734-66-5

Synonyms: XL-139

BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).

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BMS-833923, CAS 1059734-66-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 46.00
10 mg	In stock	$ 74.00
25 mg	In stock	$ 129.00
50 mg	In stock	$ 208.00
100 mg	In stock	$ 376.00
200 mg	In stock	$ 553.00
500 mg	In stock	$ 878.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 99.74%

Purity: 99.61%

Purity: 99.47%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
Targets&IC50	BODIPY:21 nM

Synonyms	XL-139
Molecular Weight	473.57
Formula	C30H27N5O
CAS No.	1059734-66-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 88 mg/mL (185.8 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Tang JY, et al. Semin Cutan Med Surg. 2011, 30(4 Suppl), S14-18. 2. Zaidi AH, et al. Cancer Invest. 2013, 31(7), 480-489. 3. Wilkinson SE, et al. Prostate. 2013, 73(16), 1810-1823.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Apoptosis Compound Library ReFRAME Related Library Stem Cell Differentiation Compound Library Reprogramming Compound Library

Related Products

Related compounds with same targets

Flavopiridol PF-573228 Tetramethylcurcumin Morroniside HLCL-61 hydrochloride PI3Kδ-IN-16 Azadirachtin KEA1-97

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-833923 1059734-66-5 Apoptosis GPCR/G Protein Stem Cells Smo Hedgehog/Smoothened Inhibitor inhibit Smoothened XL 139 XL139 BMS 833923 XL-139 BMS833923 inhibitor

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