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ALLO-2

Catalog No. T14188 CAS 1357350-60-7

ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

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ALLO-2, CAS 1357350-60-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

Molecular Weight	371.32
Formula	C18H12F3N5O
CAS No.	1357350-60-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (336.64 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18(4):432-7.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library GPCR Compound Library Anti-Pancreatic Cancer Compound Library Stem Cell Differentiation Compound Library Neuronal Signaling Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

Glasdegib HhAntag Triparanol SMANT hydrochloride MRT-10 GSA-10 HPI 1 TAK-441

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ALLO-2 1357350-60-7 G蛋白偶联受体干细胞 Hedgehog/Smoothened Smo Inhibitor inhibit ALLO 2 Smoothened ALLO2 inhibitor

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