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HhAntag

Catalog No. T3460 CAS 496794-70-8

HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity.

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HhAntag, CAS 496794-70-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity.

Molecular Weight	450.92
Formula	C24H23ClN4O3
CAS No.	496794-70-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Actis, Marcelo; Connelly, Michele C.; Mayasundari, Anand et al. A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription. Biopolymers (2011), 95(1), 24-30. 2. Mahindroo, Neeraj; Connelly, Michele C.; Punchihewa, Chandanamali; et al. Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway. Bioorganic & Medicinal Chemistry (2010), 18(13), 4801-4811. 3. Yauch, Robert L.; Gould, Stephen E.; Scales, Suzie J.; et al. A paracrine requirement for hedgehog signalling in cancer. Nature (London, United Kingdom) (2008), 455(7211), 406-410.

Citations

1. Li H, Ou J, Li Y, et al. ISX-9 potentiates CaMKIIδ-mediated BMAL1 activation to enhance circadian amplitude. Communications Biology. 2022, 5(1): 1-13.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Preclinical Compound Library GPCR Compound Library Anti-Obesity Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Wnt/Hedgehog/Notch Compound Library Anti-Cancer Active Compound Library Stem Cell Differentiation Compound Library Neuronal Signaling Compound Library

Related Products

Related compounds with same targets

Glasdegib HhAntag Triparanol SMANT hydrochloride MRT-10 GSA-10 HPI 1 TAK-441

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HhAntag 496794-70-8 G蛋白偶联受体干细胞 Hedgehog/Smoothened Smo Smoothened Inhibitor inhibit inhibitor

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