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HhAntag

Name: HhAntag
Brand: TargetMol
SKU: T3460
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3460Cas No. 496794-70-8

HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity.

HhAntag

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Purity: 95.73%

Catalog No. T3460Cas No. 496794-70-8

HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity.

Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$98	In Stock
10 mg	$188	In Stock
25 mg	$398	In Stock
50 mg	$679	In Stock
100 mg	$1,080	In Stock
1 mL x 10 mM (in DMSO)	$112	In Stock

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Batch Information

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Purity:95.73%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description

HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity.

Chemical Properties

Molecular Weight	450.92
Formula	C₂₄H₂₃ClN₄O₃
Cas No.	496794-70-8
Smiles	COc1cc(OC)cc(c1)C(=O)Nc1ccc(Cl)c(c1)-c1nc2cc(ccc2[nH]1)N(C)C
Relative Density.	1.337 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (121.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2177 mL	11.0884 mL	22.1769 mL	110.8844 mL
5 mM	0.4435 mL	2.2177 mL	4.4354 mL	22.1769 mL
10 mM	0.2218 mL	1.1088 mL	2.2177 mL	11.0884 mL
20 mM	0.1109 mL	0.5544 mL	1.1088 mL	5.5442 mL
50 mM	0.0444 mL	0.2218 mL	0.4435 mL	2.2177 mL
100 mM	0.0222 mL	0.1109 mL	0.2218 mL	1.1088 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc