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Search Result

Search Results for " smad3 "

Targets

Phosphatase Others

12

Compounds

3

Natural Products

16

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T9205 NCGC00378430 Phosphatase , Others
NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.
T3636 (E)-SIS3 SIS3,SIS3 HCl TGF-beta/Smad
(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblas...
T9953 BT173 Others
BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.
T15572 IN-1130 ALK
IN-1130 is a selective inhibitor of ALK5 with IC50 values of 5.3 nM, 36 nM, and 4.3 μM for phosphorylation of ALK5-mediated Smad3, ALK5 phosphorylation of casein and p38α mitogen-activated protein kinase.
T2247 KenPaullone 9-Bromopaullone,NSC-664704 GSK-3 , CDK
KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp...
T24470 Mitochonic Acid 35 MA35,MA-35,MA 35,Mitochonic Acid-35
Mitochonic Acid 35 is a dual TNF-α and TGF-β1 inhibitor that acts by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation.
T12923 (Rac)-SIS3 free base TGF-beta/Smad
SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.
T80628 Myristoyl tetrapeptide-12 TGF-beta/Smad
Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].
T72383 3,3-Dimethyl-1-butanol Neohexanol,DMB,DMB ; Neohexanol
3,3-Dimethyl-1-butanol (DMB) is an orally active compound that inhibits trimethylamine (TMA) and trimethylamine N-oxide (TMAO), along with the signaling pathways of p65 NF-κB and TGF-β1/Smad3. It holds potential for use ...
T74544 (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual-target PROTAC capable of directing ubiquitination and degradation of Smad3 while also elevating HIF-α protein levels. This compound exhibits both multipath anti...
T61203 ALK5-IN-8
ALK5-IN-8 is a highly effective inhibitor of TGFβRI (ALK5). It hinders the phosphorylation of ALK5 on downstream signaling proteins (Smad2 or Smad3) by obstructing the interaction between TGFβRI and ligands. Consequently...
T61586 TGFβ-IN-2
TGFβ-IN-2 (Compound 9d) effectively inhibits the accumulation of total collagen induced by TGF-β in NRK-49F cells, with an IC 50 value of 4.31 μM. It also suppresses the in vitro protein expression of COL1A1, α-SMA, and ...
Cat No. Product Name Synonyms Targets
T14854 Caerulomycin A Cerulomycin,Caerulomycin Antifungal
Caerulomycin A (Caerulomycin) (Cerulomycin; Caerulomycin) is an antifungal compound. Which induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antif...
T6856 Halofuginone Tempostatin,empostatin,RU-19110 Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
T4938 Potassium 1H-indol-3-yl sulfate Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate AhR , Endogenous Metabolite
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of imm...

Natural Products

Caerulomycin A
T14854
Synonym: Cerulomycin,Caerulomycin
Target: Antifungal
Halofuginone
T6856
Synonym: Tempostatin,empostatin,RU-19110
Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Potassium 1H-indol-3-yl sulfate
T4938
Synonym: Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate
Target: AhR, Endogenous Metabolite

Recombinant Proteins

Species：
Human (13)
Mouse (2)
Human,Mouse,Rat (1)
Expression System：
E. coli (7)
Baculovirus Insect Cells (4)
HEK293 Cells (3)
P. pastoris (Yeast) (2)
Tag：
N-6xHis (3)
C-6xHis (2)
His, GST (2)
C-hFc (1)
C-mFc (1)
His (1)
His, NusA (1)
N-10xHis (1)
N-10xHis, C-Myc (1)
N-6xHis-Flag (1)
Cat No. Product Name Species Expression System
TMPJ-00271 SMAD3 Protein, Human, Recombinant (His & Flag) Human E. coli
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so...
TMPH-01700 SMAD3 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
SMAD3 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 50.6 kDa and the accession number is P84022.
TMPY-03419 SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST) Human,Mouse,Rat Baculovirus Insect Cells
SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is...
TMPH-02055 RBPMS Protein, Human, Recombinant (His & Myc) Human E. coli
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 an...
TMPH-02866 RBBP9 Protein, Mouse, Recombinant (His) Mouse P. pastoris (Yeast)
Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due ...
TMPH-01413 GDF11 Protein, Human, Recombinant (His & SUMO) Human E. coli
Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral pattern...
TMPJ-00936 CCND2 Protein, Human, Recombinant (His) Human E. coli
CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each ...
TMPY-04203 RAB1B Protein, Human, Recombinant (hFc) Human HEK293 Cells
RAB1B, a member of the RAS oncogene family, was significantly down-regulated in highly metastatic breast cancer cells. Moreover, down-regulation of RAB1B was also found to promote the proliferation and migration of TNBC ...
TMPY-02444 ATF2 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Activating transcription factor 2, also known as ATF2, is a member of the leucine zipper family of DNA-binding proteins that binds to the cAMP response element. Its activity is enhanced after phosphorylation by stress-ac...
TMPJ-01108 SMAD4 Protein, Human, Recombinant (His) Human E. coli
SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric...
TMPH-01269 SMURF2 Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMA...
TMPY-03861 Amelotin Protein, Human, Recombinant (mFc) Human HEK293 Cells
Amelotin (AMTN) is a tooth enamel protein which is expressed in maturation-stage ameloblasts and also in the internal basal lamina of junctional epithelium, a unique epithelial structure attached to the tooth surface whi...
TMPY-04422 Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotran...
TMPJ-01178 TGFBR1 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Pho...
TMPH-03764 YAP1 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor su...
TMPY-04468 STK16 Protein, Human, Recombinant (His & NusA) Human E. coli
Serine/threonine-protein kinase 16, also known as myristoylated and palmitoylated serine/threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein that is...
SMAD3 Protein, Human, Recombinant (His & Flag)
TMPJ-00271
Species: Human
Expression System: E. coli
SMAD3 Protein, Human, Recombinant (His)
TMPH-01700
Species: Human
Expression System: Baculovirus Insect Cells
SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST)
TMPY-03419
Species: Human,Mouse,Rat
Expression System: Baculovirus Insect Cells
RBPMS Protein, Human, Recombinant (His & Myc)
TMPH-02055
Species: Human
Expression System: E. coli
RBBP9 Protein, Mouse, Recombinant (His)
TMPH-02866
Species: Mouse
Expression System: P. pastoris (Yeast)
GDF11 Protein, Human, Recombinant (His & SUMO)
TMPH-01413
Species: Human
Expression System: E. coli
CCND2 Protein, Human, Recombinant (His)
TMPJ-00936
Species: Human
Expression System: E. coli
RAB1B Protein, Human, Recombinant (hFc)
TMPY-04203
Species: Human
Expression System: HEK293 Cells
ATF2 Protein, Human, Recombinant (His & GST)
TMPY-02444
Species: Human
Expression System: Baculovirus Insect Cells
SMAD4 Protein, Human, Recombinant (His)
TMPJ-01108
Species: Human
Expression System: E. coli
SMURF2 Protein, Human, Recombinant (His)
TMPH-01269
Species: Human
Expression System: E. coli
Amelotin Protein, Human, Recombinant (mFc)
TMPY-03861
Species: Human
Expression System: HEK293 Cells
Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His)
TMPY-04422
Species: Human
Expression System: Baculovirus Insect Cells
TGFBR1 Protein, Mouse, Recombinant (hFc)
TMPJ-01178
Species: Mouse
Expression System: HEK293 Cells
YAP1 Protein, Human, Recombinant (His)
TMPH-03764
Species: Human
Expression System: P. pastoris (Yeast)
STK16 Protein, Human, Recombinant (His & NusA)
TMPY-04468
Species: Human
Expression System: E. coli
Cat No. Product Name
L4100 TGF-beta/Smad Compound Library

184 compounds
A unique collection of 184 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening;

Libraries

TGF-beta/Smad Compound Library
L4100
Compounds: 184
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